Property Summary

NCBI Gene PubMed Count 525
PubMed Score 10795.33
PubTator Score 473.56

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 2.76172585266347E-33
breast carcinoma 1614 8.48097413259925E-23
Breast cancer 3099 1.43872102720319E-10
ulcerative colitis 2087 6.73477253547328E-8
lung cancer 4473 3.65561041397264E-7
nasopharyngeal carcinoma 1056 1.9933371170371E-6
medulloblastoma, large-cell 6234 7.93976638317805E-6
group 3 medulloblastoma 2254 4.26307107392888E-5
tuberculosis 1563 1.10089719482466E-4
Atopic dermatitis 944 1.15001940844478E-4
psoriasis 6685 1.99281081940573E-4
pituitary cancer 1972 4.43505281368697E-4
invasive ductal carcinoma 2950 0.00133439298822522
ovarian cancer 8492 0.00226077891059471
pancreatic cancer 2300 0.00618423452947362
interstitial lung disease 292 0.011551022558656
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0233429791895519
primitive neuroectodermal tumor 3031 0.0234244923900651
lung adenocarcinoma 2714 0.0280143709977462
primary pancreatic ductal adenocarcinoma 1271 0.0289455602034874
Barrett's esophagus 185 0.0305284563955743
atypical teratoid/rhabdoid tumor 1095 0.0352056847720024
spina bifida 1064 0.0406802064606008
chronic rhinosinusitis 512 0.0479500109398463


  Differential Expression (24)

Disease log2 FC p
interstitial lung disease -1.600 0.012
Barrett's esophagus 1.400 0.031
psoriasis -2.300 0.000
group 3 medulloblastoma -2.600 0.000
medulloblastoma, large-cell -2.800 0.000
primitive neuroectodermal tumor -1.400 0.023
Atopic dermatitis -1.600 0.000
tuberculosis -3.200 0.000
primary pancreatic ductal adenocarcinoma 1.185 0.029
intraductal papillary-mucinous adenoma (... 1.200 0.023
lung cancer -3.600 0.000
atypical teratoid/rhabdoid tumor -1.100 0.035
nasopharyngeal carcinoma -2.800 0.000
lung adenocarcinoma -1.047 0.028
lung carcinoma -2.900 0.000
breast carcinoma -1.300 0.000
spina bifida -2.147 0.041
Breast cancer -2.300 0.000
invasive ductal carcinoma -1.800 0.001
ulcerative colitis 2.800 0.000
ovarian cancer -1.400 0.002
pituitary cancer -2.100 0.000
chronic rhinosinusitis -1.018 0.048
pancreatic cancer 1.400 0.006


Accession P13726 D3DT47 Q6FHG2 Q86WH4 TF
Symbols TF




1AHW   1BOY   1DAN   1FAK   1J9C   1JPS   1NL8   1O5D   1TFH   1UJ3   1W0Y   1W2K   1WQV   1WSS   1WTG   1WUN   1WV7   1Z6J   2A2Q   2AEI   2AER   2B7D   2B8O   2C4F   2CEF   2CEH   2CEZ   2CFJ   2EC9   2F9B   2FIR   2FLB   2FLR   2HFT   2PUQ   2ZP0   2ZWL   2ZZU   3ELA   3TH2   3TH3   3TH4   4IBL   4M7L   4YLQ   4Z6A   4ZMA  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG

Gene RIF (483)

27057091 The findings of the study show an increased expression of tissue factor in the lesional and perilesional skin of patients with bullous pemphigoid. The expression of TF was not observed in biopsies from healthy people and dermatitis herpetiformis patients.
26797521 We conclude that API M358R inhibits FVIIa by forming inhibitory complexes of the serpin type more rapidly than AT in the absence of heparin.
26791271 This study suggests that ROCK/YAP/Egr-1 signaling regulates tissue factor expression after stimulation with lipopolysaccharide in endothelial cells.
26731648 Data indicate that IGF-binding protein 3 (IGFBP3) and F3 gene expression levels in formalin fixed paraffin embedded (FFPE) prostate cancer tissue would provide an improved survival prediction for prostate cancer patients.
26694616 Data suggest that allosteric regulation of FVIIa activity by tissue factor/thromboplastin binding appear to involve direct interaction with FVIIa active site, stabilizing segment 215-217, activating loop 3, and leading to enhanced FVIIa activity.
26631725 Activation of P2Y2R increased TF promoter activity and mRNA expression in coronary artery endothelial cells.
26504080 B-Raf(V600E) mutation in metastatic melanoma cells up-regulated tissue factor expression on cell membranes and promoted thrombin production
26471500 expression by myeloid cells affects macrophage differentiation, and regulate Mycobacterium tuberculosis growth
26408927 TF plays more fundamental roles in cancer biology. TF regulates tumor cell dormancy, is associated with cancer stem cell behavior, epithelial-to-mesenchymal transition, and dictates establishment of the tumor cell premetastatic niche.
26408926 Clinical Significance of Tissue Factor-Exposing Microparticles in Arterial and Venous Thrombosis.

AA Sequence

GVGQSWKENSPLNVS                                                           281 - 295

Text Mined References (526)

PMID Year Title
27057091 2015 Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases.
26797521 2016 The M358R variant of ?(1)-proteinase inhibitor inhibits coagulation factor VIIa.
26791271 2016 Yes-associated protein (YAP) signaling regulates lipopolysaccharide-induced tissue factor expression in human endothelial cells.
26731648 2016 Improving the Prediction of Prostate Cancer Overall Survival by Supplementing Readily Available Clinical Data with Gene Expression Levels of IGFBP3 and F3 in Formalin-Fixed Paraffin Embedded Core Needle Biopsy Material.
26694616 2016 Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.
26631725 2016 Purinergic P2Y2 Receptor Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: NEW AP-1 TRANSCRIPTION FACTOR SITE AND NEGATIVE REGULATOR.
26504080 2016 Mutant B-Raf(V600E) Promotes Melanoma Paracellular Transmigration by Inducing Thrombin-mediated Endothelial Junction Breakdown.
26471500 2016 Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
26408927 2015 Tissue Factor: Old and New Links with Cancer Biology.
26408926 2015 Clinical Significance of Tissue Factor-Exposing Microparticles in Arterial and Venous Thrombosis.