Tbio ACP5 Tartrate-resistant acid phosphatase type 5

Protein Summary

Description

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• P13686
• A8K3V2
• Q2TAB1
• Q6IAS6
• Q9UCJ5
• Q9UCJ6
• Q9UCJ7
• TR-AP

Gene Name

• ACP5

Ensembl ID

• ENST00000218758
• ENSP00000218758
• ENSG00000102575
• ENST00000412435
• ENSP00000392374
• ENST00000433365
• ENSP00000413456
• ENST00000592828
• ENSP00000468767
• ENST00000648477
• ENSP00000496973

Symbol

• HPAP
• TRAP
• TRACP5a
• TRACP5b
• TrATPase

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.8
transcription factor	0.76
biological process	0.72
biological term	0.63
chemical	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2607.32   (req: < 5)

Gene RIFs: 76   (req: <= 3)

Antibodies: 534   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2607.32   (req: >= 5)

Gene RIFs: 76   (req: > 3)

Antibodies: 534   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0