Tclin RARG Retinoic acid receptor gamma

Protein Summary

Description

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P13631
• B7Z492
• B7Z4F1
• B7ZAE4
• J3KNP6
• P22932
• Q15281
• Q52LZ8
• Q9BYX8
• Q9H1I3
• Q9UJ38
• RAR-gamma

Gene Name

• RARG

Ensembl ID

• ENST00000338561
• ENSP00000343698
• ENSG00000172819
• ENST00000394426
• ENSP00000377947
• ENST00000425354
• ENSP00000388510
• ENST00000543726
• ENSP00000444335

Symbol

• NR1B3
• RARC
• NR1B3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
molecular function	0.98
PubMedID	0.95
protein domain	0.85
histone modification site profile	0.82

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Retinoic Acid Receptor Gamma

Protein / Receptor / Retinoic Acid Receptor Gamma

Protein / Nucleic Acid Binding / Retinoic Acid Receptor Gamma

Protein / ... / C4 Zinc Finger Nuclear Receptor / Retinoic Acid Receptor Gamma

DTO Classes

Protein / Nuclear Receptor / Retinoic Acid Receptors / Retinoic Acid Receptor Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.01   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.01   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 125

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6