Property Summary

NCBI Gene PubMed Count 560
PubMed Score 2314.54
PubTator Score 1704.78

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 5.67847528149822E-21
malignant mesothelioma 3163 5.20136742029178E-10
juvenile dermatomyositis 1189 3.88466488208682E-6
lung cancer 4473 4.06400329929517E-6
non-small cell lung cancer 2798 2.22173962993951E-5
lung adenocarcinoma 2714 1.40853335534452E-4
cutaneous lupus erythematosus 1056 3.98984133789223E-4
posterior fossa group A ependymoma 1511 4.40887424298718E-4
primary Sjogren syndrome 789 0.00286776521748736
adult high grade glioma 2148 0.00837597153540812
subependymal giant cell astrocytoma 2287 0.0118143547516399
atypical teratoid / rhabdoid tumor 4369 0.0122886277871046
glioblastoma 5572 0.0126588052387757
mucosa-associated lymphoid tissue lymphoma 480 0.0149287284641322
acute myeloid leukemia 785 0.0150022457927849
ovarian cancer 8492 0.0161287009729321
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0201059270321471
active Crohn's disease 918 0.0218661151427339
primitive neuroectodermal tumor 3031 0.0224213418367089
nasopharyngeal carcinoma 1056 0.0234442134924564
invasive ductal carcinoma 2950 0.0235312908901291
sarcoidosis 368 0.0249713099434164
interstitial cystitis 2299 0.0256385463363181
cystic fibrosis 1670 0.0431554854412758



Accession P13501 O43646 Q0QVW8 Q4ZGJ1 Q9NYA2 Q9UBG2 Q9UC99
Symbols SISd



1B3A   1EQT   1HRJ   1RTN   1RTO   1U4L   1U4M   1U4P   1U4R   2L9H   2VXW   5CMD   5COY   5DNF  

Gene RIF (598)

26790618 ERalpha decreased CCL5 and IL-6 expression in conditioned media that was collected from Cancer associated fibroblast cell.
26728495 This is the first study to note that elevated systemic CCL5 and CXCL6 were associated with moderate/severe lumbar disc degeneration. These chemokines may be systemic biomarkers for the diagnosis and monitoring of disc degeneration.
26699196 co-cultures of KYSE-410 cells and cancer-associated fibroblasts (CAF) were investigated. Similar to SF, Has2 and Ccl5 were up-regulated and Ccl11 was down-regulated in CAF in co-culture.
26659570 neutrophil-borne human neutrophil peptide 1 (HNP1, alpha-defensin) and platelet-derived CCL5 form heteromers.
26647394 CCL5 signaling through CCR5 may increase platelet counts during physiological stress.
26620981 findings demonstrated that CCL5 gene -28C>G polymorphism might be a protective factor for the development of TB
26585233 High CCL5 expression is associated with neurofibromatosis-1 Glioma.
26420723 CCL-5-mediated cancer cell migration and invasion are discussed in the context of intertwined feedback loops between breast cancer cells and stromal cells. [review]
26390883 Study provides the evidence that the chemokine receptor CCR5 is highly expressed and associated with poor prognosis in human glioblastoma. Mechanistically, CCL5-CCR5 mediates activation of Akt, and subsequently induces proliferation and invasive responses in U87 and U251 cells.
26363360 Nuclear beta-catenin localization is related to increased CCL5 production in breast cancer.

AA Sequence

QVCANPEKKWVREYINSLEMS                                                      71 - 91

Text Mined References (561)

PMID Year Title
26790618 2016 Estrogen receptor ? in cancer associated fibroblasts suppresses prostate cancer invasion via reducing CCL5, IL6 and macrophage infiltration in the tumor microenvironment.
26728495 2016 Systemic blood plasma CCL5 and CXCL6: Potential biomarkers for human lumbar disc degeneration.
26699196 2016 Esophageal Squamous Cell Carcinoma Cells Modulate Chemokine Expression and Hyaluronan Synthesis in Fibroblasts.
26659570 2015 Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5.
26647394 2016 CCL5 derived from platelets increases megakaryocyte proplatelet formation.
26620981 2015 The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility.
26585233 2015 RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth.
26420723 2015 Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer.
26390883 2015 Critical roles of chemokine receptor CCR5 in regulating glioblastoma proliferation and invasion.
26363360 2015 The ?-catenin signaling pathway induces aggressive potential in breast cancer by up-regulating the chemokine CCL5.