Property Summary

NCBI Gene PubMed Count 1,120
PubMed Score 6604.23
PubTator Score 4030.37

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count P-value
posterior fossa group A ependymoma 1511 7.64218242054696E-12
non-small cell lung cancer 2798 1.34858748350003E-10
lung carcinoma 2844 2.24062109572955E-10
pilocytic astrocytoma 3086 1.5247396647891E-9
lung cancer 4473 3.7834970131731E-7
juvenile dermatomyositis 1189 4.55880918991167E-7
adrenocortical carcinoma 1427 2.54653858530447E-6
cystic fibrosis 1670 4.32627867680328E-6
interstitial cystitis 2299 4.59872377948516E-5
adult high grade glioma 2148 8.38498759706979E-5
pituitary cancer 1972 1.82768154858688E-4
invasive ductal carcinoma 2950 1.85284281463197E-4
ulcerative colitis 2087 3.07850453264762E-4
atypical teratoid / rhabdoid tumor 4369 0.00124099583283703
adrenocortical adenoma 134 0.00178476479403395
cutaneous lupus erythematosus 1056 0.00226038172856052
nasopharyngeal carcinoma 1056 0.0023777341349553
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00521250164102609
lung adenocarcinoma 2714 0.00532274168554926
ovarian cancer 8492 0.00564925002658235
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00577829508370363
Atopic dermatitis 944 0.00763636894287415
systemic lupus erythematosus 172 0.0187535666448312
non diabetic and post-ischemic heart failure 200 0.0195622268640589
Gaucher disease type 3 76 0.0249829333852415
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0251438952996893
glioblastoma 5572 0.028407688366751
head and neck cancer 270 0.037171423531996
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0411962630709785
Disease Target Count Z-score Confidence
Crohn's disease 304 0.0 1.0

Expression

Synonym

Accession P13500 B2R4V3 Q9UDF3
Symbols HC11
MCAF
MCP1
MCP-1
SCYA2
GDCF-2
SMC-CF
HSMCR30

Gene

PDB

1DOK   1DOL   1DOM   1DON   1MCA   1ML0   2BDN   2NZ1   3IFD   4DN4   4R8I   4ZK9  

  Ortholog (7)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG
Rat OMA EggNOG
Dog OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid

Gene RIF (1217)

PMID Text
27363047 This study showed that the detection of MCP-1 expression relates to the response to interferon-alpha2 in combination with ribavirin in hepacivirus genotype 4 infection.
26943967 The genotypic distributions of MCP-1 (-2518 A>G) were significantly different between patients and controls.
26881918 Our results suggested that TNF-alpha may be an ideal biomarker for diagnosing the 3 forms of TB presentation, while the other factors (IL-6, IP-10, MCP-1, and IFN-gamma) can potentially facilitate differential diagnosis for the 3 TB presentation types
26867220 MCP1 may have a role in coronary artery calcium progression in patients with HIV infection on stable antiretroviral therapy
26825581 Results indicate that urinary MCP-1 was associated with blood pressure elevation in this population of obese young adults.
26802601 The results of our study suggest an association between the CCL2 gene rs1024611 G allele and post transplant diabetes mellitus in patients treated with tacrolimus or cyclosporine.
26714421 local inflammatory marker for cerebral aneurysms without systemic manifestation
26684239 Increased CCL2 expression is associated with resistance to vemurafenib in melanoma.
26648448 These findings suggested that the CCL2/CCR2 chemokine signaling may regulate the epithelial-mesenchymal transition.
26626202 our data confirmed the relevance of the MCP1 gene as a risk locus to Pott's disease in a trans-populational manner.
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AA Sequence

MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIV      1 - 70
AKEICADPKQKWVQDSMDHLDKQTQTPKT                                              71 - 99
//

Text Mined References (1123)

PMID Year Title
27363047 2016 MONOCYTE CHEMOTACTIC PROTEIN AND RESPONSE TO PEGYLATED INTERFERON-ALPHA-2A TREATMENT IN PATIENTS WITH CHRONIC HEPATITIS C (CHC) GENOTYPE 4.
26943967 2016 Association of ICAM-1 (K469E) and MCP-1 -2518 A>G gene polymorphism with brain abscess.
26881918 2016 Analysis of Plasma Cytokine and Chemokine Profiles in Patients with and without Tuberculosis by Liquid Array-Based Multiplexed Immunoassays.
26867220 2016 Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy.
26825581 2016 Urinary angiotensinogen excretion is associated with blood pressure in obese young adults.
26802601 2016 CCL2 gene polymorphism is associated with post-transplant diabetes mellitus.
26714421 2015 Serum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms.
26684239 2016 Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b.
26648448 2016 N-methyl-N-nitro-N'-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2-mediated migration.
26626202 2016 Functional polymorphisms of Monocyte Chemoattractant Protein-1 gene and Pott's disease risk.
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