Tchem CCL2 C-C motif chemokine 2

Protein Summary

Description

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P13500
• B2R4V3
• Q9UDF3

Gene Name

• CCL2

Ensembl ID

• ENST00000225831
• ENSP00000225831
• ENSG00000108691

Symbol

• MCP1
• SCYA2
• HC11
• MCAF
• MCP1
• MCP-1
• SCYA2
• GDCF-2
• SMC-CF
• HSMCR30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
gene perturbation	1
phenotype	0.98

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 2

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10759.38   (req: < 5)

Gene RIFs: 1377   (req: <= 3)

Antibodies: 1581   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10759.38   (req: >= 5)

Gene RIFs: 1377   (req: > 3)

Antibodies: 1581   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0