Property Summary

NCBI Gene PubMed Count 40
Grant Count 183
R01 Count 55
Funding $48,378,865.16
PubMed Score 640.48
PubTator Score 53.78

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (5)

Disease log2 FC p
malignant mesothelioma -1.400 0.000
psoriasis 1.900 0.000
lung cancer 1.400 0.041
diabetes mellitus -1.200 0.003
ovarian cancer -1.900 0.000

Synonym

Accession P13489 Q8IZK8 Q96FD7 Q9BQ80 Q9UDK6
Symbols RAI
RNH

Gene

PDB

1A4Y   1Z7X   2BEX   2Q4G  

Gene RIF (20)

PMID Text
25193113 a novel mechanism of ANG in regulating PI3K/AKT/mTOR signaling pathway via RI, is reported.
24769129 angiogenin and ILK signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth
24768914 RI could play a novel role in inhibiting metastasis of bladder cancer through regulating EMT and ILK signaling pathways.
24107847 RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria.
23703635 RI might play a novel role in the development of bladder cancer through regulating EMT and the ILK signaling pathway.
23584480 RNH1 as a regulator of HDACi resistance in gastric cancer
22944692 Positional proteomics analysis identifies the cleavage of human ribonuclease/angiogenin inhibitor 1 (RNH1) at amino acid residues 445-446 by the HIV-1 protease
22190034 Positional proteomics analysis identifies the cleavage of human ribonuclease/angiogenin inhibitor 1 (RNH1) at amino acid residues 445-446 by the HIV-1 protease
22162762 PTEN-mediated miR-21 regulation is achieved by inhibiting the interaction between the Drosha complex and RNH1, revealing previously unidentified role of PTEN in the oncogenic miR-21 biogenesis
21276451 RNH1 (as a recombinant fusion protein) is localized to mitochondria, nuclei, and cytosol in HeLa and HCT cells; RNH1 appears to bind to various mitochondrial proteins.
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AA Sequence

MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGD      1 - 70
VGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP     71 - 140
QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG    141 - 210
VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL    211 - 280
RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISN    281 - 350
NRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE    351 - 420
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS                                 421 - 461
//

Text Mined References (54)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
25193113 2014 Angiogenin interacts with ribonuclease inhibitor regulating PI3K/AKT/mTOR signaling pathway in bladder cancer cells.
24769129 2014 Ribonuclease inhibitor up-regulation inhibits the growth and induces apoptosis in murine melanoma cells through repression of angiogenin and ILK/PI3K/AKT signaling pathway.
24768914 2014 Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial-mesenchymal transition and ILK signaling pathway.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24107847 2014 An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract.
23703635 2013 A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells.
23584480 2014 RNH1 regulation of reactive oxygen species contributes to histone deacetylase inhibitor resistance in gastric cancer cells.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
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