Tbio IFI30 Gamma-interferon-inducible lysosomal thiol reductase

Protein Summary

Description

Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13284
• Q76MF9
• Q8NEI4
• Q8WU77
• Q9UL08

Gene Name

• IFI30

Ensembl ID

• ENST00000407280
• ENSP00000384886
• ENSG00000216490

Symbol

• GILT
• IP30
• GILT
• IP30
• IP-30
• IFI-30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
kinase perturbation	0.88
disease perturbation	0.87
PubMedID	0.84
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Gamma-interferon-inducible Lysosomal Thiol Reductase

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Gamma-interferon-inducible Lysosomal Thiol Reductase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.19   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.19   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0