Property Summary

NCBI Gene PubMed Count 18
Grant Count 32
R01 Count 5
Funding $4,028,282.75
PubMed Score 141.37
PubTator Score 45.90

Knowledge Summary

Patent

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TINX Plot

Gene RIF (10)

PMID Text
26116226 The lysosomal thiol reductase GILT expressed by antigen-presenting cells has diverse cellular and organismal functions. (Review)
24667918 Microarray analysis indicates HIV-1 Tat-induced upregulation of interferon, gamma-inducible protein 30 (IFI30) in primary human brain microvascular endothelial cells
23246037 this review discusses recent studies that have advanced our understanding of the role of GILT in antigen processing and revealed surprising new functions for the enzyme.[review]
21701784 Single nucleotide polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals.
20668223 GILT is required for efficient histocompatiblity class II-restricted processing of melanoma antigen tyrosinase-related protein 1 epitope in vitro and accelerates the onset of vitiligo in TRP1-specific T-cell receptor transgenic mice.
19240061 Observational study of gene-disease association. (HuGE Navigator)
18410276 studied gene expression profile of brain lesions of a patient with Neuromyelitis optica by using DNA microarray; found marked up-regulation of interferon gamma-inducible protein 30 (IFI30), CD163, and secreted phosphoprotein 1 (SPP1, osteopontin)
18343923 GILT-expressing melanoma cells could prove to be very promising for direct antigen presentation and CD4+ T cell recognition
12198183 Role of the C-terminal propeptide in the activity and maturation of gamma -interferon-inducible lysosomal thiol reductase (GILT).
12021307 Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes.

AA Sequence

MTLSPLLLFLPPLLLLLDVPTAAVQASPLQALDFFGNGPPVNYKTGNLYLRGPLKKSNAPLVNVTLYYEA      1 - 70
LCGGCRAFLIRELFPTWLLVMEILNVTLVPYGNAQEQNVSGRWEFKCQHGEEECKFNKVEACVLDELDME     71 - 140
LAFLTIVCMEEFEDMERSLPLCLQLYAPGLSPDTIMECAMGDRGMQLMHANAQRTDALQPPHEYVPWVTV    141 - 210
NGKPLEDQTQLLTLVCQLYQGKKPDVCPSSTSSLRSVCFK                                  211 - 250
//

Text Mined References (24)

PMID Year Title
26116226 2015 Diverse cellular and organismal functions of the lysosomal thiol reductase GILT.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23246037 2013 Expanding roles for GILT in immunity.
21701784 2012 A polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals.
21269460 2011 Initial characterization of the human central proteome.
20668223 2010 GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1.
19240061 2009 Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
18410276 2008 Neuromyelitis optica/Devic's disease: gene expression profiling of brain lesions.
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