ALAS1
5-aminolevulinate synthase, nonspecific, mitochondrial
Protein Summary
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
- ENST00000310271
- ENSP00000309259
- ENSG00000023330
- ENST00000394965
- ENSP00000378416
- ENST00000469224
- ENSP00000417719
- ENST00000484952
- ENSP00000418779
- ALAS3
- ALASH
- ALAS
- MIG4
- ALAS3
- ALASH
- ALAS-H
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 1 | ||
protein domain | 0.92 | ||
histone modification site profile | 0.84 | ||
gene perturbation | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.15 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 249 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.15 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 249 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1