Property Summary

NCBI Gene PubMed Count 125
PubMed Score 208.20
PubTator Score 640.35

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Urticaria 53
Drug Eruptions 18
Drug allergy 36
Disease Target Count P-value
non-small cell lung cancer 2798 7.7710434323993E-24
head and neck cancer 270 1.29646642411233E-6
tuberculosis and treatment for 3 months 327 8.35137770135866E-6
ovarian cancer 8492 1.20413213489103E-5
osteosarcoma 7933 2.3589922269981E-4
lung cancer 4473 2.77265875809782E-4
psoriasis 6685 3.52835841092031E-4
head and neck cancer and chronic obstructive pulmonary disease 237 8.76449720987785E-4
cutaneous lupus erythematosus 1056 0.00103508719333984
pilocytic astrocytoma 3086 0.00478460795745458
invasive ductal carcinoma 2950 0.00500328765384961
pancreatic cancer 2300 0.00572203289154433
pancreatic carcinoma 567 0.00572203289154434
interstitial cystitis 2299 0.0136510387339517
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0232821700290229
esophageal adenocarcinoma 737 0.0248700697146099
mucosa-associated lymphoid tissue lymphoma 480 0.0360306591260734
Barrett's esophagus 185 0.0360487418714976
acute myeloid leukemia 785 0.0366766161359344

Expression

Synonym

Accession P12319
Symbols FCE1A
FcERI

Gene

PANTHER Protein Class (1)

PDB

1F6A   2Y7Q   1ALS   1ALT   1F2Q   1J86   1J87   1J88   1J89   1RPQ  

  Ortholog (7)

 GWAS Trait (1)

Gene RIF (110)

PMID Text
26774660 IgG2 and IgG3 are involved in recruiting CD32 to inhibit activation of FcepsilonRI in human basophils.
26707911 F-AFE containing anti-allergic phytochemicals, including arctigenin, inhibited the activation of the FceRI receptor induced by the antigenIgE complex
26626992 Asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) Fc epsilon RI(+) blood mast cell progenitors than asthmatics with normal lung function.
26136426 Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation
25923080 SNPs of FcepsilonR1alpha promoter region may be used as disease markers for IgE-mediated allergic inflammation caused by Dermatophagoides pteronyssinus.
25713122 FcepsilonRI alpha-chain is an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand.
25412950 These data suggest that rs2298805 might be associated with risk for Chronic urticaria and the therapeutic efficacy of nonsedating H1-antihistamines in Chinese patients
24610015 Data indicate that antigen (Ag) targeting to FcepsilonRI inhibits the development of Ag-specific T cell immunity and induces T cell tolerance.
24569373 FCER1A expressing dendritic cells and monocytes but not basophils, significantly contribute to serum hIgE clearance.
24361879 Overexpression of miR-142-3p enhances FcepsilonRI-mediated degranulation.
More...

AA Sequence

MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSL      1 - 70
SEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDV     71 - 140
YKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPL    141 - 210
LVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN                           211 - 257
//

Text Mined References (126)

PMID Year Title
26774660 2016 Parameters determining the efficacy of CD32 to inhibit activation of Fc?RI in human basophils.
26707911 2016 Inhibitory effect of fermented Arctium lappa fruit extract on the IgE-mediated allergic response in RBL?2H3 cells.
26626992 2016 Lin- CD34hi CD117int/hi Fc?RI+ cells in human blood constitute a rare population of mast cell progenitors.
26136426 2015 Tetraspanin CD151 Is a Negative Regulator of Fc?RI-Mediated Mast Cell Activation.
25923080 2015 An Exploratory Pilot Study of Genetic Marker for IgE-Mediated Allergic Diseases with Expressions of Fc?R1? and C?.
25713122 2015 A Human Platelet Receptor Protein Microarray Identifies the High Affinity Immunoglobulin E Receptor Subunit ? (Fc?R1?) as an Activating Platelet Endothelium Aggregation Receptor 1 (PEAR1) Ligand.
25412950 2015 Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients.
24610015 2014 Antigen-conjugated human IgE induces antigen-specific T cell tolerance in a humanized mouse model.
24569373 2014 Serum IgE clearance is facilitated by human Fc?RI internalization.
24361879 2014 miR-142-3p enhances Fc?RI-mediated degranulation in mast cells.
More...