Tclin IMPDH2 Inosine-5'-monophosphate dehydrogenase 2

Protein Summary

Description

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P12268
• Q6LEF3
• IMP dehydrogenase 2

Gene Name

• IMPDH2

Ensembl ID

• ENST00000326739
• ENSP00000321584
• ENSG00000178035

Symbol

• IMPD2
• IMPD2
• IMPDH-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
kinase perturbation	1
transcription factor perturbation	0.97
small molecule perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Inosine-5'-monophosphate Dehydrogenase 2

Protein / Oxidoreductase / Dehydrogenase / Inosine-5'-monophosphate Dehydrogenase 2

Protein / ... / Metalloprotease / Inosine-5'-monophosphate Dehydrogenase 2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Inosine-5'-monophosphate Dehydrogenase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.83   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 346   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.83   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 491

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3