COL6A2
Collagen alpha-2(VI) chain
Protein Summary
Collagen VI acts as a cell-binding protein. This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000300527
- ENSP00000300527
- ENSG00000142173
- ENST00000310645
- ENSP00000312529
- ENST00000397763
- ENSP00000380870
- ENST00000409416
- ENSP00000387115
- UCMD1
- BTHLM1
- PP3610
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.88 | ||
disease perturbation | 0.79 | ||
kinase perturbation | 0.76 | ||
phenotype | 0.64 | ||
small molecule perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.31 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 221 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.31 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 221 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0