Property Summary

NCBI Gene PubMed Count 453
PubMed Score 11.53
PubTator Score 4332.84

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
breast carcinoma 1614 6.32731294354057E-30
non-small cell lung cancer 2798 1.76800473196772E-19
astrocytoma 1493 1.02871703637346E-11
juvenile dermatomyositis 1189 1.32861147174981E-10
oligodendroglioma 2849 1.82575979231126E-9
acute quadriplegic myopathy 1157 2.28423964699826E-8
nasopharyngeal carcinoma 1056 2.61728607058215E-7
lung cancer 4473 2.0629345929659E-6
atypical teratoid/rhabdoid tumor 1095 2.30742267423083E-6
medulloblastoma, large-cell 6234 1.72622463724505E-5
pituitary cancer 1972 3.11016589574436E-5
primitive neuroectodermal tumor 3031 5.40510435595393E-5
lung adenocarcinoma 2714 6.214859183775E-5
ovarian cancer 8492 8.61788156138929E-5
pediatric high grade glioma 2712 9.76728124339511E-5
group 3 medulloblastoma 2254 1.77982568256758E-4
glioblastoma 5572 2.40010411883823E-4
invasive ductal carcinoma 2950 3.58476459058596E-4
dermatomyositis 967 5.4736531600191E-4
ductal carcinoma in situ 1745 0.00117224544254556
primary Sjogren syndrome 789 0.00518700566220374
Waldenstrons macroglobulinemia 765 0.00598981474463126
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0243219506140263
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0253846582502252
Endometriosis 535 0.0255376186429833
Breast cancer 3099 0.0383733611956839
Disease Target Count Z-score Confidence
Neurodegenerative disease 383 0.0 4.0



Accession P12004 B2R897 D3DW02 PCNA
Symbols ATLD2



1U7B   1UL1   5E0V   4ZTD   3P87   1AXC   1U76   1VYJ   1VYM   1W60   2ZVK   2ZVL   2ZVM   3JA9   3TBL   3VKX   3WGW   4D2G   4RJF   5E0T   5E0U   5IY4  

  Ortholog (16)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG
Mouse OMA Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid
C. elegans OMA Inparanoid
Fruitfly OMA Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (308)

26731993 data indicated that IncRNA-PCNA-AS1 may participate in the gastric cancer carcinogenesis and development and may serve as a new biomarker for patients with gastric cancer
26688547 The authors describe the structure of the disease-causing S228I variant, which reveals a large conformational change that dramatically transforms the binding pocket for PCNA client proteins.
26673319 USP7 suppresses H2O2-induced mutagenesis involving cell-cycle-independent processes such as DNA repair.
26557712 Effect of Fenugreek seed extract (FCE) was studied using HepG2 cell line; evaluated apoptosis effect and changes in expression of PCNA and tp53 due to FCE.
26450907 Studies show that acidic residue methyltransferase 1 (Armt1) has a vital role in regulation of the DNA damage response likely through its ability to O-methylate glutamyl residues of the DNA repair factor proliferating cell nuclear antigen (PCNA).
26408825 Hydrophobic pocket of PCNA is the key domain mediating ALKBH2/PCNA interaction. PCNA association with ALKBH2 increases significantly during DNA replication, suggesting that ALKBH2 forms a cell-cycle dependent complex with PCNA.
26377631 adenine glycosylase activity, mismatch recognition properties and interaction with protein partners of MUTYH and 5 MAP variants were examined; P502L and R520Q had reduced affinity for PCNA; only Q324H was found to have reduced affinity for Hus1
26339416 Report PCNA expression in giant cell tumor of bones.
26223641 Bub1 in complex with LANA recruits PCNA to regulate Kaposi's sarcoma-associated herpesvirus latent replication and DNA translesion synthesis.
26117423 The expression of BAF180 promotes UV-induced PCNA ubiquitination during S phase.

AA Sequence


Text Mined References (467)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
26731993 2015 High Expression of IncRNA-PCNA-AS1 in Human Gastric Cancer and its Clinical Significances.
26688547 2016 A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
26673319 2015 USP7 Is a Suppressor of PCNA Ubiquitination and Oxidative-Stress-Induced Mutagenesis in Human Cells.
26557712 2015 Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26450907 2015 Armt1: a phoenix rises from the ashes.
26408825 2015 The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.
26377631 2015 Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.
26339416 2015 Expression of CD147, PCNA, VEGF, MMPs and their clinical significance in the giant cell tumor of bones.