Property Summary

NCBI Gene PubMed Count 20
PubMed Score 48.83
PubTator Score 16.44

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
tuberculosis 1563 8.10070084758545E-7
Multiple myeloma 1328 7.41703366030897E-5
atypical teratoid / rhabdoid tumor 4369 2.75989141175603E-4
glioblastoma 5572 0.00120147118703294
adrenocortical adenoma 134 0.00336317391351437
astrocytic glioma 2241 0.00363091659268029
adrenocortical carcinoma 1427 0.00375355762560993
medulloblastoma 1524 0.00481482463227777
Waldenstrons macroglobulinemia 765 0.00492338358964237
medulloblastoma, large-cell 6234 0.00501652909907847
ependymoma 2514 0.0053797637625985
oligodendroglioma 2849 0.0128440586893248
ovarian cancer 8492 0.0166678420917248
osteosarcoma 7933 0.0175996654481728
Polycystic Ovary Syndrome 335 0.0207106935977244
primitive neuroectodermal tumor 3031 0.0217181829035583

Expression

  Differential Expression (16)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.310 0.005
Multiple myeloma 1.387 0.000
astrocytic glioma -2.800 0.004
oligodendroglioma -2.800 0.013
osteosarcoma -1.352 0.018
ependymoma -1.100 0.005
atypical teratoid / rhabdoid tumor -1.100 0.000
glioblastoma -1.200 0.001
medulloblastoma -1.700 0.005
medulloblastoma, large-cell -1.600 0.005
primitive neuroectodermal tumor -1.300 0.022
adrenocortical adenoma -2.699 0.003
adrenocortical carcinoma -2.347 0.004
tuberculosis 1.300 0.000
Polycystic Ovary Syndrome 1.251 0.021
ovarian cancer -1.100 0.017

Synonym

Accession P11908 Q0VDH9 Q0VDI0 Q15245 Q2TAK7
Symbols PRSII

Gene

PANTHER Protein Class (3)

  Ortholog (11)

Species Source
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA EggNOG
Pig OMA Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA EggNOG
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG
S.cerevisiae OMA EggNOG

Gene RIF (5)

PMID Text
26004865 PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway.
25816608 The expression of different genes encoding subunits of PRPS enzyme is affected by hypoxia in tumor glioma cells, but the effect of hypoxia is modified by suppression of endoplasmic reticulum stress signaling enzyme ERN1.
25149475 Meta-analysis of genome-wide association studies identifies a novel variant in PRPS2 on Xp22.3 as susceptibility locus for systemic lupus erythematosus.
18677108 Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets.
18409517 increased activity of this gene leads to gout

AA Sequence

MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMEL      1 - 70
LIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDI     71 - 140
PVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGD    141 - 210
VKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDK    211 - 280
MKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL                                    281 - 318
//

Text Mined References (21)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26004865 2015 PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.
25816608 Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.
25416956 2014 A proteome-scale map of the human interactome network.
25149475 2015 Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
21269460 2011 Initial characterization of the human central proteome.
18677108 2008 Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
18409517 2008 [Increased activity of PRPP synthetase].
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
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