MS4A1
B-lymphocyte antigen CD20
Protein Summary
This protein may be involved in the regulation of B-cell activation and proliferation. This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
- ENST00000345732
- ENSP00000314620
- ENSG00000156738
- ENST00000389939
- ENSP00000374589
- ENST00000528313
- ENSP00000432270
- ENST00000534668
- ENSP00000433277
- CD20
- B1
- S7
- Bp35
- CD20
- CVID5
- MS4A2
- LEU-16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.83 | ||
cell line | 0.73 | ||
kinase | 0.63 | ||
microRNA | 0.56 | ||
PubMedID | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.17 (req: < 5)
Gene RIFs: 116 (req: <= 3)
Antibodies: 3294 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.17 (req: >= 5)
Gene RIFs: 116 (req: > 3)
Antibodies: 3294 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5