Tchem ESRRA Steroid hormone receptor ERR1

Protein Summary

Description

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• P11474
• Q14514

Gene Name

• ESRRA

Ensembl ID

• ENST00000000442
• ENSP00000000442
• ENSG00000173153
• ENST00000405666
• ENSP00000384851
• ENST00000406310
• ENSP00000385971

Symbol

• ERR1
• ESRL1
• NR3B1
• ERR1
• ERRa
• ESRL1
• NR3B1
• ERRalpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
protein domain	0.92
transcription factor binding site profile	0.91
transcription factor	0.88
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Steroid Hormone Receptor Err1

Protein / Receptor / Steroid Hormone Receptor Err1

Protein / Nucleic Acid Binding / Steroid Hormone Receptor Err1

Protein / ... / C4 Zinc Finger Nuclear Receptor / Steroid Hormone Receptor Err1

DTO Classes

Protein / Nuclear Receptor / Estrogen-related Receptors / Steroid Hormone Receptor Err1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.16   (req: < 5)

Gene RIFs: 158   (req: <= 3)

Antibodies: 488   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.16   (req: >= 5)

Gene RIFs: 158   (req: > 3)

Antibodies: 488   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 89

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3