Tclin VDR Vitamin D3 receptor

Protein Summary

Description

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]

Uniprot Accession IDs

• P11473
• B2R5Q1
• G3V1V9
• Q5PSV3
• VDR

Gene Name

• VDR

Ensembl ID

• ENST00000229022
• ENSP00000229022
• ENSG00000111424
• ENST00000395324
• ENSP00000378734
• ENST00000549336
• ENSP00000449573
• ENST00000550325
• ENSP00000447173

Symbol

• NR1I1
• NR1I1
• PPP1R163

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.99
virus perturbation	0.98
hub protein	0.97
chemical	0.95

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Vitamin D3 Receptor

Protein / Receptor / Vitamin D3 Receptor

Protein / Nucleic Acid Binding / Vitamin D3 Receptor

Protein / ... / C4 Zinc Finger Nuclear Receptor / Vitamin D3 Receptor

DTO Classes

Protein / Nuclear Receptor / Vitamin D Receptor-like Receptors / Vitamin D3 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1523.16   (req: < 5)

Gene RIFs: 1903   (req: <= 3)

Antibodies: 722   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1523.16   (req: >= 5)

Gene RIFs: 1903   (req: > 3)

Antibodies: 722   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 246

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9