Tbio ACADM Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Protein Summary

Description

Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P11310
• Q5T4U4
• Q9NYF1
• MCAD

Gene Name

• ACADM

Ensembl ID

• ENST00000370841
• ENSP00000359878
• ENSG00000117054
• ENST00000420607
• ENSP00000409612

Symbol

• MCAD
• ACAD1
• MCADH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
kinase perturbation	0.93
interacting protein	0.8
transcription factor binding site profile	0.76
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Medium-chain Specific Acyl-coa Dehydrogenase, Mitochondrial

Protein / Oxidoreductase / Oxidase / Medium-chain Specific Acyl-coa Dehydrogenase, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Medium-chain Specific Acyl-coa Dehydrogenase, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Medium-chain Specific Acyl-coa Dehydrogenase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.51   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 407   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.51   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0