Tclin BCR Breakpoint cluster region protein

Protein Summary

Description

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P11274
• P78501
• Q12842
• Q4LE80
• Q6NZI3

Gene Name

• BCR

Ensembl ID

• ENST00000305877
• ENSP00000303507
• ENSG00000186716
• ENST00000359540
• ENSP00000352535

Symbol

• BCR1
• D22S11
• ALL
• CML
• PHL
• BCR1
• D22S11
• D22S662

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
molecular function	0.99
protein domain	0.97
kinase	0.91
biological process	0.9

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Breakpoint Cluster Region Protein

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Breakpoint Cluster Region Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.65   (req: < 5)

Gene RIFs: 300   (req: <= 3)

Antibodies: 599   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.65   (req: >= 5)

Gene RIFs: 300   (req: > 3)

Antibodies: 599   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11