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  6. Ras-related protein Ral-B

Tbio Ras-related protein Ral-B

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).

This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 48
PubMed Score 50.92
PubTator Score 46.00

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7
Disease Target Count Z-score Confidence
Cancer 2499 3.288 1.6

Expression

  Differential Expression (8)

Disease log2 FC p
astrocytic glioma -1.300 9.7e-03
ependymoma -1.100 4.3e-02
group 3 medulloblastoma -1.100 1.1e-02
malignant mesothelioma -1.100 5.4e-05
medulloblastoma, large-cell -1.700 2.5e-04
osteosarcoma 2.549 3.5e-07
psoriasis 1.400 1.8e-03
Rheumatoid arthritis -1.400 1.3e-02

Synonym

Accession P11234 B4E040 Q53T32 Q6ZS74
Symbols

Gene

RALB

PANTHER Protein Class (3)

PDB

2KE5   2KWI  

  Ortholog (1)

Species Source Disease
Mouse OMA EggNOG Inparanoid

 UniProt Keyword (14)

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 GO Function (5)

 GO Component (4)

 GO Process (14)

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 Compartment GO Term (13)

 IMPC Phenotype (1)

 MGI Phenotype (9)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (21)

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Protein-protein Interaction (7)

ALDH18A1   TPP2   ANKRD13A   XPO5   PAM   DBT   MAPK14  

Gene RIF (33)

AA Sequence 

MAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTA      1 - 70
GQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPV     71 - 140
EEARSKAEEWGVQYVETSAKTRANVDKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERCCLL        141 - 206
//

Text Mined References (53)

PMID Year Title