| Tbio | Ras-related protein Ral-B |
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 44 |
| Grant Count | 68 |
| R01 Count | 54 |
| Funding | $4,290,731.98 |
| PubMed Score | 49.70 |
| PubTator Score | 46.00 |
| Disease | log2 FC | p |
|---|---|---|
| Rheumatoid Arthritis | -1.400 | 0.013 |
| malignant mesothelioma | -1.100 | 0.000 |
| astrocytic glioma | -1.300 | 0.010 |
| ependymoma | -1.100 | 0.043 |
| psoriasis | 2.600 | 0.000 |
| osteosarcoma | 2.549 | 0.000 |
| medulloblastoma, large-cell | -1.700 | 0.000 |
| group 4 medulloblastoma | -1.300 | 0.000 |
| PMID | Text |
|---|---|
| 26216878 | striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB. |
| 25573158 | These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I. |
| 25210032 | expression of K-Ras and RalB and possibly RalA proteins is critical for maintaining low levels of p53, and down-regulation of these GTPases reactivates p53 by significantly enhancing its stability, contributing to suppression of malignant transformation |
| 24747441 | Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance. |
| 24389431 | High RALB mRNA expression is associated with non-small-cell lung cancer growth and progression. |
| 24056301 | nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles |
| 23830877 | RalA and RalB exhibit both distinct and redundant roles in tumorigenesis (Review). |
| 22790202 | The study found upregulated RalA and RalB activation in colorectal cancer tumor cell lines and tumors. |
| 22700969 | the existence of an ubiquitination/de-ubiquitination cycle superimposed on the GDP/GTP cycle of RalA, involved in the regulation of RalA activity as well as in membrane raft trafficking. |
| 22393054 | phosphorylation by PKCalpha is critical for RalB-mediated vesicle trafficking and exocytosis. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26216878 | 2015 | Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases. |
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 25573158 | 2015 | Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion. |
| 25210032 | 2014 | Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation. |
| 24747441 | 2014 | An integrin ??-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. |
| 24389431 | 2013 | Contributions of KRAS and RAL in non-small-cell lung cancer growth and progression. |
| 24056301 | 2013 | The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. |
| 23830877 | 2013 | Ral GTPases in tumorigenesis: emerging from the shadows. |
| 23533145 | 2013 | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. |
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
| More... |
