Tclin GHR Growth hormone receptor

Protein Summary

Description

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• P10912
• Q9HCX2
• GH receptor

Gene Name

• GHR

Ensembl ID

• ENST00000230882
• ENSP00000230882
• ENSG00000112964
• ENST00000357703
• ENSP00000350335
• ENST00000537449
• ENSP00000442206
• ENST00000612382
• ENSP00000478332
• ENST00000612626
• ENSP00000479846
• ENST00000615111
• ENSP00000478291
• ENST00000618088
• ENSP00000482373

Symbol

• GHBP
• GHIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
disease perturbation	0.96
biological process	0.95
PubMedID	0.92
hub protein	0.88

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Growth Hormone Receptor

Protein / Defense/immunity Protein / Growth Hormone Receptor

DTO Classes

Protein / Signaling / Cytokine / Growth Hormone Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1107.19   (req: < 5)

Gene RIFs: 222   (req: <= 3)

Antibodies: 362   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1107.19   (req: >= 5)

Gene RIFs: 222   (req: > 3)

Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6