| Tclin | Thyroid hormone receptor alpha |
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 104 |
| NCBI Gene PubMed Count | 136 |
| PubMed Score | 527.45 |
| PubTator Score | 229.05 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Endometriosis | 540 | 0.0 | 0.0 |
| HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 6 | 1 | 0.0 | 0.0 |
| Hernia, Diaphragmatic | 40 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 4.8e-09 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.0e-08 |
| ovarian cancer | 8520 | 2.0e-08 |
| breast carcinoma | 1638 | 1.6e-07 |
| osteosarcoma | 7950 | 1.4e-06 |
| sonic hedgehog group medulloblastoma | 467 | 8.1e-06 |
| medulloblastoma, large-cell | 6241 | 1.3e-05 |
| psoriasis | 6694 | 1.0e-04 |
| malignant mesothelioma | 3232 | 1.4e-04 |
| glioblastoma | 5792 | 6.1e-04 |
| adult high grade glioma | 3801 | 1.8e-03 |
| subependymal giant cell astrocytoma | 2287 | 9.0e-03 |
| Disease | Target Count |
|---|---|
| Peripheral resistance to thyroid hormones | 2 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.200 | 1.8e-03 |
| atypical teratoid / rhabdoid tumor | -1.300 | 1.0e-08 |
| breast carcinoma | -1.500 | 1.6e-07 |
| glioblastoma | -1.200 | 6.1e-04 |
| lung adenocarcinoma | -1.600 | 4.8e-09 |
| malignant mesothelioma | -1.100 | 1.4e-04 |
| medulloblastoma, large-cell | -1.200 | 1.3e-05 |
| osteosarcoma | -2.119 | 1.4e-06 |
| ovarian cancer | -1.200 | 2.0e-08 |
| psoriasis | -2.100 | 1.0e-04 |
| sonic hedgehog group medulloblastoma | -1.200 | 8.1e-06 |
| subependymal giant cell astrocytoma | -1.276 | 9.0e-03 |
CHEMBL3126376
pEC50 7.00
CHEMBL250104
pIC50 7.00
CHEMBL236438
pIC50 7.00
CHEMBL195079
pIC50 7.00
CHEMBL392925
pIC50 7.02
CHEMBL109279
pKd 7.03
CHEMBL238178
pIC50 7.03
CHEMBL2312262
pKi 7.04
CHEMBL3397346
pKi 7.05
CHEMBL236499
pIC50 7.06
CHEMBL264153
pEC50 7.06
CHEMBL249445
pIC50 7.07
CHEMBL440975
pIC50 7.08
CHEMBL264410
pKd 7.09
CHEMBL250308
pIC50 7.11
CHEMBL2035879
pKi 7.16
CHEMBL485928
pKi 7.21
CHEMBL372428
pIC50 7.21
CHEMBL235384
pIC50 7.30
CHEMBL193615
pIC50 7.32
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITC 1 - 70 EGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQ 71 - 140 NRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKV 141 - 210 DLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 211 - 280 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFE 281 - 350 HYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL 351 - 420 GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP 421 - 490 //
