Tclin RARB Retinoic acid receptor beta

Protein Summary

Description

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• P10826
• P12891
• Q00989
• Q15298
• Q9UN48
• RAR-beta

Gene Name

• RARB

Ensembl ID

• ENST00000330688
• ENSP00000332296
• ENSG00000077092
• ENST00000437042
• ENSP00000398840
• ENST00000458646
• ENSP00000391391

Symbol

• HAP
• NR1B2
• HAP
• RRB2
• NR1B2
• MCOPS12
• RARbeta1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
biological process	0.97
trait	0.93
protein domain	0.85
PubMedID	0.83

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Retinoic Acid Receptor Beta

Protein / Receptor / Retinoic Acid Receptor Beta

Protein / Nucleic Acid Binding / Retinoic Acid Receptor Beta

Protein / ... / C4 Zinc Finger Nuclear Receptor / Retinoic Acid Receptor Beta

DTO Classes

Protein / Nuclear Receptor / Retinoic Acid Receptors / Retinoic Acid Receptor Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.27   (req: < 5)

Gene RIFs: 198   (req: <= 3)

Antibodies: 487   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.27   (req: >= 5)

Gene RIFs: 198   (req: > 3)

Antibodies: 487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 143

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7