Property Summary

NCBI Gene PubMed Count 281
PubMed Score 107.13
PubTator Score 1843.49

Knowledge Summary


No data available


  Disease Sources (3)


  Differential Expression (8)

Disease log2 FC p
cutaneous lupus erythematosus 2.800 0.001
osteosarcoma -1.966 0.001
lung cancer -1.100 0.006
interstitial cystitis 1.800 0.004
primary Sjogren syndrome 1.500 0.027
sarcoidosis -1.600 0.000
ovarian cancer -2.300 0.000
psoriasis 1.700 0.000



PANTHER Protein Class (2)


5AUL   3WA4   1YJD  

  Ortholog (13)

Gene RIF (282)

26950734 expansion of highly differentiated CD28null T cells is associated with a lower risk for early acute rejection after kidney transplantation
26885860 in complex with T cell receptor, promotes glycolysis
26408701 Results showed lower and higher serum levels of CTLA4 and CD28 detected respectively in patients with colorectal cancer (CRC)and found an association of the CTLA4 -318C/T polymorphism in CRC patients.
26405154 A highly recurrent novel missense mutation in CD28 among angioimmunoblastic T-cell lymphoma patients.
26403483 These findings indicate that the associations of the CTLA-4 and CD28 polymorphisms with the risk of renal cancer are worth further study in a larger group of patients.
26375412 In patients presenting with acute coronary syndrome, the CD4 + CD28null T cell percentage was higher in patients with non-ST-segment-elevation acute coronary syndrome versus those with STEMI.
26277688 Among CD8+ T-lymphocytes, CD28+CD57+ cells represent a subset with some senescent features that are distinct from the CD28-CD57+ cells.
26215444 The functional decline of invariant natural killer T cells was closely related to the decrease in CD28 expression and the increases of Tim-3 and PD-1.
26043137 study also uncovered a previously unappreciated role for Vav1 in crosstalk between the CD28 and TCR signaling pathways
26041540 CD58/CD2 is the primary costimulatory pathway in human CD28-CD8+ T cells.

AA Sequence

PPRDFAAYRS                                                                211 - 220

Text Mined References (287)

PMID Year Title
26950734 2016 Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation.
26885860 2016 Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.
26408701 2015 Individual and Combined Effects of CTLA4-CD28 Variants and Oxidant-Antioxidant Status on the Development of Colorectal Cancer.
26405154 2015 A highly recurrent novel missense mutation in CD28 among angioimmunoblastic T-cell lymphoma patients.
26403483 2015 CTLA-4 and CD28 genes' polymorphisms and renal cell carcinoma susceptibility in the Polish population--a prospective study.
26375412 2015 CD4+CD28null T cells in acute coronary syndrome: lower with ST-elevation myocardial infarction.
26277688 Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes.
26215444 2015 Roles of the programmed cell death 1, T cell immunoglobulin mucin-3, and cluster of differentiation 288 pathways in the low reactivity of invariant natural killer T cells after chronic hepatitis B virus infection.
26043137 2015 Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.
26041540 2015 CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28-CD8+ T Cells.