MAPT
Microtubule-associated protein tau
Protein Summary
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontot ...more
- ENST00000262410
- ENSP00000262410
- ENSG00000186868
- ENST00000334239
- ENSP00000334886
- ENST00000340799
- ENSP00000340438
- ENST00000344290
- ENSP00000340820
- ENST00000351559
- ENSP00000303214
- ENST00000415613
- ENSP00000410838
- ENST00000420682
- ENSP00000413056
- ENST00000431008
- ENSP00000389250
- ENST00000446361
- ENSP00000408975
- ENST00000535772
- ENSP00000443028
- ENST00000571987
- ENSP00000458742
- ENST00000574436
- ENSP00000460965
- ENST00000612872
- ENSP00000478602
- ENSG00000277956
- ENST00000613360
- ENSP00000483784
- ENSG00000276155
- ENST00000620070
- ENSP00000484491
- ENST00000620818
- ENSP00000484321
- ENST00000620981
- ENSP00000481769
- ENST00000621329
- ENSP00000477703
- ENST00000622106
- ENSP00000482244
- ENST00000622728
- ENSP00000479142
- ENST00000626571
- ENSP00000486039
- ENST00000628393
- ENSP00000487570
- ENST00000631447
- ENSP00000488373
- ENST00000632500
- ENSP00000487837
- ENST00000633047
- ENSP00000488245
- ENST00000634049
- ENSP00000487819
- MAPTL
- MTBT1
- TAU
- TAU
- MSTD
- PPND
- DDPAC
- MAPTL
- MTBT1
- MTBT2
- FTDP-17
- PPP1R103
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
phosphatase | 0.99 | ||
PubMedID | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9015.14 (req: < 5)
Gene RIFs: 1788 (req: <= 3)
Antibodies: 4894 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9015.14 (req: >= 5)
Gene RIFs: 1788 (req: > 3)
Antibodies: 4894 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 81
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 120
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2