Property Summary

NCBI Gene PubMed Count 36
PubMed Score 38.99
PubTator Score 34.60

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count
Adenoid Cystic Carcinoma 99
Disease Target Count P-value
lung adenocarcinoma 2714 2.77696430007989E-8
Breast cancer 3099 8.6383863508185E-8
lung cancer 4473 4.15301403479566E-5
Multiple Sclerosis 498 9.22276584982298E-5
hepatocellular carcinoma 550 5.94730714860942E-4
diabetes mellitus 1663 0.00291835702972201
gastric cancer 436 0.0189768858088725


  Differential Expression (7)

Disease log2 FC p
gastric cancer -1.600 0.019
hepatocellular carcinoma -1.500 0.001
lung cancer 1.700 0.000
diabetes mellitus -1.200 0.003
Multiple Sclerosis -1.600 0.000
lung adenocarcinoma 1.800 0.000
Breast cancer 1.400 0.000


Accession P10412 Q4VB25
Symbols H1E



5JJZ   3TZD  

  Ortholog (5)

Species Source
Chimp OMA EggNOG
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid

Gene RIF (11)

25048004 This study identified and confirmed HIST1H1E protein changes within the postsynaptic density in schizophrenia.
24873882 Histone H1.2-T165 post translational modifications are dispensable for chromatin binding and cell proliferation while the H1.4-K26 modifications are essential for proper cell cycle progression.
24435047 Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.
22465951 H1.4K34 acetylation is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor.
22425985 the N-terminal domain of H1 is an important determinant of affinity and specificity of H1-chromatin interactions.
21852232 PKA-mediated H1.4S35 phosphorylation dissociates H1.4 from mitotic chromatin but also suggest that this phosphorylation is necessary for specific mitotic functions.
21425800 Overexpression of NPM1 enhances HIV-1 Tat-mediated transactivation by reducing the histone H1 occupancy on the chromatinized template of HIV-1 LTR
20800603 Observational study of gene-disease association. (HuGE Navigator)
19144645 Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
15595731 the lysine residue adjacent to the phosphorylation site found on the serine residue on the H1.4 peptide KARKSAGAAKR was also shown to be methylated, raising the question of whether the hypothesized "methyl/phos" switch could be extended to linker histones

AA Sequence

PKKAAAKKK                                                                 211 - 219

Text Mined References (48)

PMID Year Title
26689747 2016 Role of H1 linker histones in mammalian development and stem cell differentiation.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25048004 2015 Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.
24873882 2014 Dynamics and dispensability of variant-specific histone H1 Lys-26/Ser-27 and Thr-165 post-translational modifications.
24435047 2014 Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.