ARAF
Serine/threonine-protein kinase A-Raf
Protein Summary
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
- ENST00000377039
- ENSP00000366238
- ENSG00000078061
- ENST00000377045
- ENSP00000366244
- ARAF1
- PKS
- PKS2
- PKS2
- A-RAF
- ARAF1
- RAFA1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
kinase perturbation | 0.97 | ||
interacting protein | 0.96 | ||
molecular function | 0.96 | ||
disease perturbation | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 624.21 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 619 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 624.21 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 619 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 9
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3