Property Summary

Ligand Count 783
NCBI Gene PubMed Count 1,968
PubMed Score 7137.71
PubTator Score 7221.94

Knowledge Summary

Patent (193,439)

TINX Plot

  Disease (10)

Disease Target Count
Male infertility 206
Gynecomastia 64
Cryptorchidism 296
Hypogonadism 173
Infertility 188
Abnormality of the rib cage 12
Absent axillary hair 5
Absent facial hair 2
Absent or rudimentary fallopian tubes 2
Absent pubic hair 2
Adult onset 82
Alcohol withdrawal syndrome 20
Alcoholic Intoxication, Chronic 289
Aplasia/Hypoplasia of the fallopian tube 2
Atrophy of testis 14
Atrophy, Muscular, Spinobulbar 1
Azoospermia 110
Bifid scrotum 16
Bulbar palsy 19
Bulbar weakness 19
Bulbo-Spinal Atrophy, X-Linked 1
Bulbospinal Neuronopathy 1
Calf muscle hypertrophy 9
Congenital absence of vas deferens 3
Congenital hypoplasia of penis 176
Craving for alcohol 3
Creatine phosphokinase serum increased 110
Decreased fertility 33
Decreased tendon reflex 122
Deglutition Disorders 132
Depressive disorder 409
Dysarthria 192
Dysphonia 7
Elevated creatine kinase 110
Elevated follicle stimulating hormone 15
Elevated luteinizing hormone 14
Erectile abnormalities 16
Female Pseudohermaphroditism 5
Female external genitalia in males 13
Female infertility 30
Gait abnormality 135
Gestational diabetes 26
Gonadal neoplasm 1
Hernia, Inguinal 89
Hypertensive disease 292
Hypospadias, perineal 5
Liver carcinoma 240
Male Pseudohermaphroditism 19
Mammary Neoplasms 425
Mental Depression 333
Mood Disorders 184
Mouth Abnormalities 14
Muscle Cramp 55
Muscle hypotonia 571
Muscle weakness of limb 21
Muscular fasciculation 22
Nephrolithiasis 56
Neurogenic Muscular Atrophy 139
Neurogenic muscle atrophy, especially in the lower limbs 139
Neuropathy 261
Osteoporosis 363
Penile hypospadias 106
Peripheral Neuropathy 134
Primary physiologic amenorrhea 55
Prostatic Intraepithelial Neoplasias 11
Reifenstein Syndrome 1
Schizophrenia 1160
Sensory neuropathy 20
Skeletal muscle atrophy 139
Slow progression 89
Sparse axillary hair 28
Sparse pubic hair 31
Tremor 113
Uterus absent (finding) 4
X- linked recessive 110
abnormal growth 26
muscle degeneration 139
Disease Target Count Z-score Confidence
DOID:9917 31 0.0 0.5
Kidney cancer 2613 0.0 0.8
Disease Target Count Z-score Confidence
Prostate cancer 175 8.134 4.0
Alopecia universalis 16 0.0 3.0
Disease Target Count Z-score Confidence
Pseudohermaphroditism 16 4.111 2.1
Neurodegenerative disease 414 0.0 4.0

Expression

  Differential Expression (19)

Disease log2 FC p
Breast cancer -2.200 4.2e-03
astrocytic glioma 1.600 2.9e-03
Atopic dermatitis -1.100 1.2e-03
atypical teratoid / rhabdoid tumor -1.600 4.3e-05
cutaneous lupus erythematosus -1.300 7.5e-03
ependymoma 1.400 1.2e-02
glioblastoma 1.200 4.8e-03
group 3 medulloblastoma -1.700 2.9e-03
interstitial cystitis -1.600 2.8e-03
intraductal papillary-mucinous adenoma (... -1.400 2.0e-03
intraductal papillary-mucinous carcinoma... -1.700 4.2e-04
intraductal papillary-mucinous neoplasm ... -1.800 3.7e-03
malignant mesothelioma 2.700 3.8e-08
medulloblastoma, large-cell -1.700 2.0e-03
osteosarcoma 1.225 1.0e-02
pancreatic ductal adenocarcinoma liver m... -2.325 5.3e-03
pituitary cancer 1.300 2.9e-02
primitive neuroectodermal tumor -1.700 1.1e-03
psoriasis -1.400 1.4e-16

Synonym

Accession P10275 A0A0B4J1T2 A2RUN2 B1AKD7 C0JKD3 C0JKD4 E7EVX6 Q9UD95
Symbols KD
AIS
AR8
TFM
DHTR
SBMA
HYSP1
NR3C4
SMAX1
HUMARA

Gene

AR

PDB

3L3X   3L3Z   1T5Z   4OED   4OH6   4OKB   1E3G   1GS4   1T63   1T65   1XJ7   1XOW   1XQ3   1Z95   2AM9   2AMA   2AMB   2AO6   2AX6   2AX7   2AX8   2AX9   2AXA   2HVC   2OZ7   2PIO   2PIP   2PIQ   2PIR   2PIT   2PIU   2PIV   2PIW   2PIX   2PKL   2PNU   2Q7I   2Q7J   2Q7K   2Q7L   2YHD   2YLO   2YLP   2YLQ   2Z4J   3B5R   3B65   3B66   3B67   3B68   3BTR   3RLJ   3RLL   3V49   3V4A   3ZQT   4HLW   4K7A   4OEA   4OEY   4OEZ   4OFR   4OFU   4OGH   4OH5   4OHA   4OIL   4OIU   4OJ9   4OJB   4OK1   4OKT   4OKW   4OKX   4OLM   4QL8   5CJ6   5JJM   5T8E   5T8J   5V8Q  

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG Inparanoid

 GWAS Trait (1)

Gene RIF (1787)

AA Sequence

MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQ      1 - 70
QQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVA     71 - 140
ASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGR    141 - 210
AREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVR    211 - 280
PTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKS    281 - 350
GALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAA    351 - 420
GPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGL    421 - 490
AGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTC    491 - 560
LICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGAR    561 - 630
KLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAA    631 - 700
LLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLV    701 - 770
FNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELD    771 - 840
RIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSG    841 - 910
KVKPIYFHTQ                                                                911 - 920
//

Text Mined References (1993)

PMID Year Title