Property Summary

NCBI Gene PubMed Count 58
PubMed Score 313.39
PubTator Score 299.96

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
IGA Glomerulonephritis 454
Disease Target Count P-value
psoriasis 6685 1.07413507825384E-15
osteosarcoma 7933 1.57548869512825E-8
pilocytic astrocytoma 3086 1.5147316627938E-7
tuberculosis 1563 5.187898479157E-7
posterior fossa group A ependymoma 1511 1.89766473503624E-5
colon cancer 1475 3.90547097292327E-5
adult high grade glioma 2148 3.97378231565252E-4
gastric cancer 436 0.00101377839259065
Waldenstrons macroglobulinemia 765 0.00133139665441034
glioblastoma 5572 0.00140003264170735
group 3 medulloblastoma 2254 0.0052228606041934
interstitial cystitis 2299 0.0357342665498995


  Differential Expression (12)

Disease log2 FC p
gastric cancer -1.200 0.001
Waldenstrons macroglobulinemia 4.362 0.001
osteosarcoma -7.371 0.000
posterior fossa group A ependymoma 1.700 0.000
glioblastoma 2.400 0.001
tuberculosis 3.100 0.000
colon cancer -2.100 0.000
interstitial cystitis 1.100 0.036
adult high grade glioma 1.800 0.000
group 3 medulloblastoma -1.300 0.005
pilocytic astrocytoma 2.000 0.000
psoriasis 1.600 0.000


Accession P10153 Q52M39 Q9H2B7 Q9UCG7
Symbols EDN



2BEX   1GQV   1HI2   1HI3   1HI4   1HI5   1K2A   2BZZ   2C01   2C02   2C05   5E13  

  Ortholog (6)

Species Source
Chimp OMA EggNOG Inparanoid
Macaque EggNOG Inparanoid
Mouse OMA EggNOG
Rat OMA Inparanoid
Horse OMA EggNOG

Gene RIF (29)

26534742 Serum EDN level may be a useful marker for monitoring persistent airflow limitation in adult patients with asthma who had positive results for house-dust-specific IgE antibodies.
25221852 RNASE2 gene expression was differentially expressed in rheumatoid arthritis patients considering a sequence polymorphism.
24890227 increased in feces after the ingestion of enterocolitis-causative foods
24814827 mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation.
23533305 A higher level of serum EDN was found specifically in patients with ALS, indicating that EDN may participate in the pathophysiology of Amyotrophic lateral sclerosis.
23053729 findings show substantial amounts of EPX/EDN localise in an extra-granular, low equilibrium density compartment of eosinophils
21680952 Eosinophil protein X in urine from asymptomatic neonates is a biomarker significantly associated with later development of allergic sensitization, nasal eosinophilia, and eczema during the first 6 years of life
19717523 ECP and EDN disrupt skin integrity and cause inflammation
19115260 the roles of the six discrete segments in transcription regulation were investigated and the -350/-329 region (ednR2) was shown to be involved in the regulation of edn expression
19014520 No variation in genes encoding eosinophil-derived neurotoxin for Atopic dermatitis pathogenesis in this German cohort.

AA Sequence

RDQRRDPPQYPVVPVHLDRII                                                     141 - 161

Text Mined References (62)

PMID Year Title
26534742 Serum eosinophil-derived neurotoxin: correlation with persistent airflow limitation in adults with house-dust mite allergic asthma.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25221852 2015 Relationship between SNPs and expression level for candidate genes in rheumatoid arthritis.
24890227 2014 Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome.
24814827 2014 Expression levels of eosinophil granule protein mRNAs in induced sputum reflect airway hyperresponsiveness and airflow limitation.
24337645 2014 Comparative genomic analysis of eutherian ribonuclease A genes.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24270810 2013 High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
23533305 2013 Eosinophil-derived neurotoxin is elevated in patients with amyotrophic lateral sclerosis.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.