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Tclin
CALCB
Calcitonin gene-related peptide 2

Protein Summary
Description
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324229
  • ENSP00000346017
  • ENSG00000175868
  • ENST00000533448
  • ENSP00000433490

Symbol
  • CALC2
  • CALC2
  • CGRP2
  • CGRP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.73
disease perturbation
0.62
tissue
0.58
histone modification site profile
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.27   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.27   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1