Tchem TMIGD3 Transmembrane domain-containing protein TMIGD3

Protein Summary

Description

Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186). This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• P0DMS9
• A2A3P4
• P33765
• Q5QNY7
• Q6P2N6
• Q6UWU0
• Q9BYZ1

Gene Name

• TMIGD3

Ensembl ID

• ENST00000369716
• ENSP00000358730
• ENSG00000121933
• ENST00000369717
• ENSP00000358731

Symbol

• AD026

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1630.19   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1630.19   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 100

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0