Property Summary

NCBI Gene PubMed Count 76
PubMed Score 27.78
PubTator Score 15.08

Knowledge Summary

Patent

No data available

TINX Plot

Expression

Synonym

Gene

Gene RIF (8)

PMID Text
25292040 Low Pepsinogen I is associated with precancerous gastric lesions.
24895149 High serum Pepsinogen I level is associ9ated with the progression of gastric precancerous lesions.
23886209 Significantly higher AUC was observed for the PGI/PGII ratio and is associated with atrophy and intestinal metaplasia.
21175799 A significant negative correlation was found between the degree of corpus atrophy and the level of serum pepsinogen-I in atrophic gastritis patients with gastroesophageal reflux.
19196398 Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan.
18844222 pepsinogens may have a role in esophageal squamous dysplasia
17559360 Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer.
15688378 Higher levels of Pepsinogen I is associated with early gastric cancer

AA Sequence

MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLEN      1 - 70
YLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTG     71 - 140
SMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQ    141 - 210
DLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGT    211 - 280
SLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQG    281 - 350
MNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA                                    351 - 388
//

Text Mined References (84)

PMID Year Title
25314140 2014 Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.
25292040 2014 Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran.
24895149 2015 Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study.
24383519 2014 The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.
24170207 2014 Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.
24125879 2014 A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.
24004680 2013 Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.
23897256 2013 Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.
23886209 2013 Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
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