Tbio TRAPPC2 Trafficking protein particle complex subunit 2

Protein Summary

Description

Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi. The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• P0DI81
• A6NEG0
• O14582
• Q9HD16

Gene Name

• TRAPPC2

Ensembl ID

• ENST00000359680
• ENSP00000352708
• ENSG00000196459
• ENST00000380579
• ENSP00000369953
• ENST00000458511
• ENSP00000392495

Symbol

• SEDL
• SEDL
• SEDT
• MIP2A
• TRS20
• ZNF547L
• hYP38334
• TRAPPC2P1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
histone modification site profile	0.92
tissue sample	0.69
disease perturbation	0.68
transcription factor perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Trafficking Protein Particle Complex Subunit 2

DTO Classes

Protein / Transcription Factor / Trafficking Protein Particle Complex Subunit 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.75   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.75   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0