Property Summary

NCBI Gene PubMed Count 13
PubMed Score 0.08

Knowledge Summary

Patent

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Gene RIF (6)

PMID Text
26990160 Humanin protected RPE cells against oxidative stress-induced cell death and restored mitochondrial function.
26216267 Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-beta.
23402768 Data suggest that humanin (the first small peptide of a putative set of mitochondrial derived peptides) exhibits strong cytoprotective actions against various stress and disease models.
22010475 The in vivo studies suggest that humanin may protect against cognitive impairment, also due to ischemia/reperfusion injury.[review]
21935731 findings implied that HN protects cortical neurons from I/R injury by the increased SOD activity and that the protective effect of HN on neurons against I/R is concentration-dependent
20542501 Immunolocalization of humanin in human sperm and testis.

AA Sequence

MAPRGFSCLLLSTSEIDLPVKRRT                                                    1 - 24
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Text Mined References (13)

PMID Year Title
26990160 2016 The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.
26216267 2015 Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-?.
25630734 2016 The human mitochondrial genome may code for more than 13 proteins.
23402768 2013 Humanin: a harbinger of mitochondrial-derived peptides?
22010475 2011 [Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities].
21935731 2012 Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.
20542501 2010 Immunolocalization of humanin in human sperm and testis.
19623253 2009 Humanin: a novel central regulator of peripheral insulin action.
19477263 2009 Evidence for potential functionality of nuclearly-encoded humanin isoforms.
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
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