Property Summary

NCBI Gene PubMed Count 199
Grant Count 107
R01 Count 49
Funding $12,394,521.1
PubMed Score 56.70
PubTator Score 187.63

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (8)

Disease log2 FC p
osteosarcoma 1.159 0.000
astrocytoma 1.200 0.006
glioblastoma 1.200 0.017
primary pancreatic ductal adenocarcinoma 1.248 0.004
lung cancer -3.400 0.043
acute myeloid leukemia 1.100 0.022
ovarian cancer 1.900 0.000
pancreatic cancer 1.200 0.014

Gene

UBC

PDB

2LVO   2LVP   2LVQ   2RR9   1XD3   3JVZ   3JW0   2Y5B   3I3T   3MTN   2HTH   1S1Q   2AYO   4NQK   1ZO6   2KHW   5E6J   1C3T   1CMX   1D3Z   1F9J   1FXT   1G6J   1GJZ   1NBF   1OGW   1Q5W   1SIF   1TBE   1UBI   1UBQ   1UD7   1XQQ   1YX5   1YX6   1ZGU   2BGF   2DEN   2FUH   2G45   2GBJ   2GBK   2GBM   2GBN   2GBR   2GMI   2IBI   2J7Q   2JF5   2JRI   2JY6   2JZZ   2K25   2K6D   2K8B   2K8C   2KDF   2KJH   2KLG   2KN5   2KX0   2L3Z   2LD9   2LZ6   2MBO   2MBQ   2MCN   2MI8   2MJ5   2MOR   2MRE   2MWS   2N2K   2NR2   2O6V   2OJR   2PE9   2PEA   2RU6   2W9N   2WDT   2XEW   2Z59   2ZCB   2ZVN   2ZVO   3A33   3ALB   3AUL   3B08   3B0A   3BY4   3C0R   3DVG   3DVN   3EEC   3EFU   3EHV   3H7P   3H7S   3HM3   3IFW   3IHP   3JSV   3K9O   3K9P   3KVF   3KW5   3LDZ   3MHS   3N30   3N32   3N3K   3NS8   3O65   3OFI   3OJ3   3OJ4   3ONS   3PRM   3PT2   3PTF   3Q3F   3RUL   3TMP   3U30   3UGB   3V6C   3V6E   3VFK   3VUW   3VUX   3VUY   3WXE   3WXF   3ZLZ   3ZNH   3ZNI   3ZNZ   4AP4   4AUQ   4BOS   4BOZ   4BVU   4DDG   4DDI   4DHJ   4DHZ   4FJV   4HK2   4HXD   4I6L   4I6N   4IG7   4IUM   4JQW   4K1R   4K7S   4K7U   4K7W   4KSK   4KSL   4LCD   4LDT   4MDK   4MM3   4MSM   4MSQ   4UN2   4V3K   4V3L   4WZP   4XOK   4XOL   4ZQS   5A5B   5AF4   5AF5   5AF6   5AIT   5AIU   5B83   5C7J   5C7M  

Gene RIF (75)

PMID Text
26782416 Our study predicted that UBC and RPA had potential as target genes for the diagnosis and treatment of osteosarcoma
26317694 Data show that at least three heat shock elements with different configurations, exist in the UBC promoter. All of them are bound by transcription factors belonging to the heat shock factor family clarifying the mechanisms regulating UBC expression.
26271983 Data show that discoidin domain receptor 2 (DDR2) is linked to a polyubiquitin (Ub) chain predominantly through lysine K27 conjugation and slightly through K33.
26171660 noncovalent ubiquitin:ubiquitin interactions are nearly identical to those reported for Lys11-linked ubiquitin and seem to play a significant role in stabilizing the crystal structure without the isopeptide bond.
26148049 Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4) together induce an active conformation of the ubiquitin-conjugating enzyme Ubc13-ubiquitin (Ubc13~Ub) thioester.
26118027 In testicular germ cell tumors, the ubiquitin expression is decreased indicating disturbances of ubiquitin-proteolysis system components at the initial stages of testicular tissue carcinogenesis.
26000850 Studies suggest that quantitative proteomic approaches would set a standard for elucidating biochemical mechanisms of Ubiquitin (UB)-driven signaling systems.
25716317 Data indicate that TRAF interacting protein TRIP negatively regulates the TNFR-associated factor 2 (TRAF2) ubiquitin-dependent pathway by modulating the TRAF2-sphingosine 1-phosphate (S1P) interaction.
25713068 Data indicate that heat shock protein 90kDa (Hsp90) inhibition suppresses 26S proteasome remodeling, unanchored ubiquitin chain production, and aggresome clearance.
25404403 USP4 requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover by promoting ubiquitin exchange.
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AA Sequence

MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV      1 - 70
LRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKE     71 - 140
STLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSD    141 - 210
YNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLED    211 - 280
GRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFA    281 - 350
GKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ    351 - 420
QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKE    421 - 490
GIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKA    491 - 560
KIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDT    561 - 630
IENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV                   631 - 685
//

Text Mined References (207)

PMID Year Title
26782416 2015 Selecting key genes associated with osteosarcoma based on a differential expression network.
26317694 2015 Molecular Dissection of the Human Ubiquitin C Promoter Reveals Heat Shock Element Architectures with Activating and Repressive Functions.
26271983 2015 [The attachment manner of ubiquitin to proinflammatory molecule discoidin domain receptor 2].
26171660 2015 Tetrameric Assembly of Monoubiquitin Accurately Mimics the Lys11 Polyubiquitin Chain Structure.
26148049 2015 Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.
26118027 [IMMUNOHISTOCHEMICAL EXPRESSION OF UBIQUITIN PROTEIN IN PERITUMORAL TISSUE OF PATIENTS WITH TESTICULAR GERM CELL TUMORS].
26000850 2015 Quantifying ubiquitin signaling.
25716317 2015 Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction.
25713068 2015 Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance.
25527291 2015 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
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