Property Summary

NCBI Gene PubMed Count 199
PubMed Score 56.70
PubTator Score 187.63

Knowledge Summary

Patent

No data available

TINX Plot

Expression

  Differential Expression (8)

Disease log2 FC p
osteosarcoma 1.159 1.1e-05
astrocytoma 1.200 6.0e-03
glioblastoma 1.200 1.7e-02
primary pancreatic ductal adenocarcinoma 1.248 3.6e-03
lung cancer -3.400 4.3e-02
acute myeloid leukemia 1.100 2.2e-02
ovarian cancer 1.900 1.4e-05
pancreatic cancer 1.200 1.4e-02

Gene

UBC

PDB

2LVO   2LVP   2LVQ   2RR9   1XD3   3JVZ   3JW0   2Y5B   3I3T   3MTN   2HTH   1S1Q   2AYO   4NQK   1ZO6   2KHW   5E6J   1C3T   1CMX   1D3Z   1F9J   1FXT   1G6J   1GJZ   1NBF   1OGW   1Q5W   1SIF   1TBE   1UBI   1UBQ   1UD7   1XQQ   1YX5   1YX6   1ZGU   2BGF   2DEN   2FUH   2G45   2GBJ   2GBK   2GBM   2GBN   2GBR   2GMI   2IBI   2J7Q   2JF5   2JRI   2JY6   2JZZ   2K25   2K6D   2K8B   2K8C   2KDF   2KJH   2KLG   2KN5   2KX0   2L3Z   2LD9   2LZ6   2MBO   2MBQ   2MCN   2MI8   2MJ5   2MOR   2MRE   2MWS   2N2K   2NR2   2O6V   2OJR   2PE9   2PEA   2RU6   2W9N   2WDT   2XEW   2Z59   2ZCB   2ZVN   2ZVO   3A33   3ALB   3AUL   3B08   3B0A   3BY4   3C0R   3DVG   3DVN   3EEC   3EFU   3EHV   3H7P   3H7S   3HM3   3IFW   3IHP   3JSV   3K9O   3K9P   3KVF   3KW5   3LDZ   3MHS   3N30   3N32   3N3K   3NS8   3O65   3OFI   3OJ3   3OJ4   3ONS   3PRM   3PT2   3PTF   3Q3F   3RUL   3TMP   3U30   3UGB   3V6C   3V6E   3VFK   3VUW   3VUX   3VUY   3WXE   3WXF   3ZLZ   3ZNH   3ZNI   3ZNZ   4AP4   4AUQ   4BOS   4BOZ   4BVU   4DDG   4DDI   4DHJ   4DHZ   4FJV   4HK2   4HXD   4I6L   4I6N   4IG7   4IUM   4JQW   4K1R   4K7S   4K7U   4K7W   4KSK   4KSL   4LCD   4LDT   4MDK   4MM3   4MSM   4MSQ   4UN2   4V3K   4V3L   4WZP   4XOK   4XOL   4ZQS   5A5B   5AF4   5AF5   5AF6   5AIT   5AIU   5B83   5C7J   5C7M  

  Ortholog (1)

Species Source Disease
Chimp EggNOG Inparanoid

Protein-protein Interaction (3)

Gene RIF (67)

PMID Text
26782416 Our study predicted that UBC and RPA had potential as target genes for the diagnosis and treatment of osteosarcoma
26317694 Data show that at least three heat shock elements with different configurations, exist in the UBC promoter. All of them are bound by transcription factors belonging to the heat shock factor family clarifying the mechanisms regulating UBC expression.
26271983 Data show that discoidin domain receptor 2 (DDR2) is linked to a polyubiquitin (Ub) chain predominantly through lysine K27 conjugation and slightly through K33.
26171660 noncovalent ubiquitin:ubiquitin interactions are nearly identical to those reported for Lys11-linked ubiquitin and seem to play a significant role in stabilizing the crystal structure without the isopeptide bond.
26148049 Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4) together induce an active conformation of the ubiquitin-conjugating enzyme Ubc13-ubiquitin (Ubc13~Ub) thioester.
26118027 In testicular germ cell tumors, the ubiquitin expression is decreased indicating disturbances of ubiquitin-proteolysis system components at the initial stages of testicular tissue carcinogenesis.
26000850 Studies suggest that quantitative proteomic approaches would set a standard for elucidating biochemical mechanisms of Ubiquitin (UB)-driven signaling systems.
25716317 Data indicate that TRAF interacting protein TRIP negatively regulates the TNFR-associated factor 2 (TRAF2) ubiquitin-dependent pathway by modulating the TRAF2-sphingosine 1-phosphate (S1P) interaction.
25713068 Data indicate that heat shock protein 90kDa (Hsp90) inhibition suppresses 26S proteasome remodeling, unanchored ubiquitin chain production, and aggresome clearance.
25404403 USP4 requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover by promoting ubiquitin exchange.
25220377 Studies indicate that ubiquitin proteasome system (UPS) controls all aspects of cholesterol metabolism including its synthesis, uptake, and efflux.
24912152 Data indicate that conditional replacement of endogenous ubiquitin (Ub) by Ub(R54A/Y59A) or Ub(K48R) yielded profound apoptosis at a similar extent.
24722446 This study identifies altered proteolysis as a feature of persistent podocyte injury. In the future, specific UPS proteins may serve as new biomarkers or therapeutic targets in persistent nephrotic syndrome.
24627472 Data indicate that a single point deletion (DeltaE81) in RAP80 abrogates multivalent interactions with polyubiquitin.
24568736 Static HMG-20 structure is derived from high precision residual dipolar couplings measured in a drug-based liquid crystalline phase using NMR spectroscopy.
24446487 UbcH5c~Ubiqitin binding stabilizes an active conformation of the Shigella flexneri OspG kinase, greatly enhancing its activity.
24366945 These results reveal an unanticipated mode of Ube2g2 self-association that allows Ube2g2 to effectively engage two ubiquitins to specifically synthesize Lys48-linked ubiquitin chains.
24318982 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
23776572 Yin Yang 1 intronic binding sequences and splicing elicit intron-mediated enhancement of ubiquitin C gene expression.
23644597 The donor ubiquitin, transferred from the E2, is bound to the Nedd4 C lobe with its C-terminal tail locked in an extended conformation, primed for catalysis.
23339974 This article reviews the recent advances in proteomics of HMG20 and reveals novel networks and associations with human disease.[review]
23300079 Data suggest that ubiquitin (Ub) binding provides a negative feedback loop upon NOD1 and NOD2 (nucleotide-binding oligomerization domain-containing proteins)-dependent activation of receptor-interacting protein kinase 2 (RIP2).
23284170 Data indicate that pressure induced ubiquitin unfolding in methanol.
23259674 Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase.
23180530 Ubiquitin's regulatory mechanisms of expression in heart failure patients' cardiomyocytes. (review)
23123110 The GP78 CUE domain functions to both facilitate substrate binding and enable switching between adjacent ubiquitin molecules of a growing chain to enable processivity in ubiquitination.
22737208 analysis of cold-induced changes in the protein ubiquitin
22605335 Data indicate that modification of NEMO with linear di-ubiquitin is sufficient for full NF-kappaB activation.
21969857 the ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein limits antigen presentation
21919991 Ubiquitin targeting of tau protein occurs at neurofibrillary tangles in the early and intermediate maturation stages.
21846465 Studies suggest that DNA damage-induced ubiquitination or sumoylation of PCNA prevents CRL4Cdt2-dependent degradation by inhibiting binding of Cdt1 to PCNA.
21802467 The human ubiquitin C promoter transgene might be useful to selectively target projections of brain neurons.
21704031 Studies indicate that All the Y-family polymerases have ubiquitin binding domains that bind to mono-ubiquitinated PCNA to effect the switching from replicative to Y-family polymerase.
21664912 Studies indicate that Non-proteolytic ubiquitylation of chromatin surrounding DSBs, mediated by the RNF8/RNF168 ubiquitin ligase cascade, has emerged as a key mechanism for restoration of genome integrity.
21640108 Studies indicate that Ku80 is removed from DNA through a ubiquitin-mediated process.
21624367 Studies indicate that Mdm2 has the ability to catalyze both mono- and poly-ubiquitination of p53.
21605556 Studies indicate that monoubiquitylation of PCNA allows mutagenic translesion synthesis by damage-tolerant DNA polymerases, polyubiquitylation is required mainly for an error-free pathway that likely involves template switching.
21549706 Studies indicate that signaling controlled by ubiquitin or ubiquitin-like proteins has recently emerged as key regulator of the cellular DNA damage response, and viruses can reveal key convergence points in this important cellular pathway.
21539841 Studies indicate that Ubiquitin- and SUMO-mediated modification pathways have emerged as key players in regulating damage-induced template switching.
21536036 Studies indicate that the involvement of the degradation-linked K48-ubiquitin signal and the proteasome at the sites of DSBs.
20688984 CHBP is an inhibitor of the ubiquitination pathway; it deamidated Gln40 in ubiquitin and ubiquitin-like protein NEDD8 in vitro and during Burkholderia infection; Cif deamidated NEDD8, abolishing activity of neddylated Cullin-RING ubiquitin ligases
20653130 Ubiquitin and UBE1 are upregulated in tic epilepsy.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20491623 Studies indicate that indicating that the inhibition of the ubiquitin-proteasome system could be used as a novel approach for cancer therapy.
19928833 The structure of UbcH8 does not undergo a significant conformational change upon forming a complex with ubiquitin.
19913121 Observational study of gene-disease association. (HuGE Navigator)
19733223 provide insights into the pivotal role of Sp1/Sp3 binding to the intronic enhancer in the regulation of UbC transcription.
19516896 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
19349673 The positive rates of ubiquitin and cul-1 were significantly higher in lung cancer than those in benign lesion tissues of the lung.
19094431 Ubiquitin expression increased with increasing severity of coronary artery disease, suggesting that ubiquitin may play a critical role in the development and progression of this disease.
18596088 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
17609272 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
17550899 Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain
17067581 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
16892003 The presence of ubiquitin mainly in the nuclei and in the cytoplasm of BPH and prostatic adenocarcinoma, respectively, may suggest a role of ubiquitin in the development of the above mentioned conditions
16808324 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
16775314 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
15994808 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
15893736 These results indicate that the use of cellular promoters such as those for EF-1alpha and ubiquitin C might direct prolonged gene expression in hematopoietic and mesenchymal progenitor cells.
12923571 the mechanical stability of ubiquitin is linkage dependent
12883554 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
12610113 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
11991975 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
11112487 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
11087860 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
11087859 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
9525617 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex

AA Sequence

MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV      1 - 70
LRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKE     71 - 140
STLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSD    141 - 210
YNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLED    211 - 280
GRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFA    281 - 350
GKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ    351 - 420
QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKE    421 - 490
GIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKA    491 - 560
KIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDT    561 - 630
IENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV                   631 - 685
//

Text Mined References (207)

PMID Year Title
26782416 2015 Selecting key genes associated with osteosarcoma based on a differential expression network.
26317694 2015 Molecular Dissection of the Human Ubiquitin C Promoter Reveals Heat Shock Element Architectures with Activating and Repressive Functions.
26271983 2015 [The attachment manner of ubiquitin to proinflammatory molecule discoidin domain receptor 2].
26171660 2015 Tetrameric Assembly of Monoubiquitin Accurately Mimics the Lys11 Polyubiquitin Chain Structure.
26148049 2015 Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.
26118027 [IMMUNOHISTOCHEMICAL EXPRESSION OF UBIQUITIN PROTEIN IN PERITUMORAL TISSUE OF PATIENTS WITH TESTICULAR GERM CELL TUMORS].
26000850 2015 Quantifying ubiquitin signaling.
25716317 2015 Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction.
25713068 2015 Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance.
25527291 2015 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
25404403 2014 The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange.
25220377 2014 The UPS and downs of cholesterol homeostasis.
24912152 2014 Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.
24784582 2014 Ubiquitin is phosphorylated by PINK1 to activate parkin.
24751536 2014 PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
24722446 2014 Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases.
24660806 2014 Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.
24627472 2014 Molecular basis for impaired DNA damage response function associated with the RAP80 ?E81 defect.
24568736 2014 Improved cross validation of a static ubiquitin structure derived from high precision residual dipolar couplings measured in a drug-based liquid crystalline phase.
24446487 2014 E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.
24366945 2014 Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains.
23827681 2013 OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
23776572 2013 Yin Yang 1 intronic binding sequences and splicing elicit intron-mediated enhancement of ubiquitin C gene expression.
23644597 2013 Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23339974 2013 Ubiquitin - omics reveals novel networks and associations with human disease.
23300079 2013 Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.
23284170 2013 High-pressure NMR reveals close similarity between cold and alcohol protein denaturation in ubiquitin.
23259674 2013 Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase.
23180530 2012 [The regulatory mechanisms of protein expression in heart failure patients' cardiomyocytes. The ubiquitin-proteasome system. Autophagy].
23123110 2012 Promiscuous interactions of gp78 E3 ligase CUE domain with polyubiquitin chains.
22795130 2012 Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.
22737208 2012 Cold-induced changes in the protein ubiquitin.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
22605335 2012 Analysis of nuclear factor-?B (NF-?B) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-?B.
21969857 2011 A ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein to limit antigen presentation.
21919991 2012 Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease.
21900206 2011 A directed protein interaction network for investigating intracellular signal transduction.
21846465 2011 Ub-family modifications at the replication fork: Regulating PCNA-interacting components.
21802467 2011 The human ubiquitin C promoter drives selective expression in principal neurons in the brain of a transgenic mouse line.
21704031 2011 Ubiquitin-family modifications in the replication of DNA damage.
21664912 2011 The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks.
21640108 2011 Destroying the ring: Freeing DNA from Ku with ubiquitin.
21630459 2011 Proteomic characterization of the human sperm nucleus.
21624367 2011 p53 regulation by ubiquitin.
21605556 2011 Timing and spacing of ubiquitin-dependent DNA damage bypass.
21549706 2011 Changing the ubiquitin landscape during viral manipulation of the DNA damage response.
21539841 2011 Ubiquitin family modifications and template switching.
21536036 2011 Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy.
21399617 2011 Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.
21185309 2011 Ubiquitin is a novel substrate for human insulin-degrading enzyme.
21150319 2010 Proteomic profiling of Myc-associated proteins.
20936779 2010 A human MAP kinase interactome.
20688984 2010 Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.
20653130 2010 [The quantitative analysis of Ub and UbE1 in focus of traumatic epilepsy].
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20622874 2010 Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.
20601937 2010 Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.
20495530 2010 Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt.
20491914 2010 The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain.
20491623 2010 The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.
20395957 2010 New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.
20150893 2010 VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo.
20059542 2010 Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis.
20006610 2010 Disease-associated variants of microsomal retinol dehydrogenase 12 (RDH12) are degraded at mutant-specific rates.
19928833 2009 The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19909340 2009 Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2.
19820695 2009 Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.
19798103 2009 Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities.
19796170 2009 Accumulation of polyubiquitinated proteins by overexpression of RBCC protein interacting with protein kinase C2, a splice variant of ubiquitin ligase RBCC protein interacting with protein kinase C1.
19779455 2009 PARP-1 transcriptional activity is regulated by sumoylation upon heat shock.
19763089 2009 NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain.
19754430 2009 The emerging complexity of protein ubiquitination.
19733223 2009 A potent enhancer element in the 5'-UTR intron is crucial for transcriptional regulation of the human ubiquitin C gene.
19680224 2009 SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation.
19619542 2009 Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19536131 2009 Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.
19427866 2009 Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover.
19407811 2009 BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.
19376117 2009 HSP70 protects BCL2L12 and BCL2L12A from N-terminal ubiquitination-mediated proteasomal degradation.
19373254 2009 Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.
19349673 2009 Expression of ubiquitin and cullin-1 and its clinicopathological significance in benign and malignant lesions of the lung.
19322201 2009 Ubiquitin-mediated proteolysis of HuR by heat shock.
19322197 2009 Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase.
19285159 2009 Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays.
19262565 2009 Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit.
19233177 2009 Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system.
19166840 2009 FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53.
19153604 2009 Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3.
19131971 2009 The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.
19111555 2009 Alternate binding modes for a ubiquitin-SH3 domain interaction studied by NMR spectroscopy.
19111546 2009 Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy.
19098711 2009 RYBP stabilizes p53 by modulating MDM2.
19094431 Expression of ubiquitin in peripheral inflammatory cells from patients with coronary artery disease.
19026640 2008 Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination.
18719106 2008 Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
18680311 2008 Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination.
18566590 2008 The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.
18566587 2008 Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.
18539162 2008 Distinct interactions between ubiquitin and the SH3 domains involved in immune signaling.
18539148 2008 HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalpha.
18388957 2008 NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
18309296 2008 Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation.
18239685 2008 Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation.
17948050 2007 Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.
17703191 2007 Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
17568776 2007 Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53.
17550899 2007 Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.
17363905 2007 Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.
17363902 2007 Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor.
17323924 2007 Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
17320083 2007 Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathway.
17318178 2007 CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha.
17318174 2007 Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation.
17304240 2007 Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta.
17290220 2007 The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.
17268548 2007 Monoubiquitylation promotes mitochondrial p53 translocation.
17255943 2007 CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.
17203973 2007 The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells.
17183367 2007 COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.
17170702 2007 Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.
17159902 2007 An essential function of the extreme C-terminus of MDM2 can be provided by MDMX.
17139261 2006 p53 mediates the negative regulation of MDM2 by orphan receptor TR3.
17110928 2006 The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17070805 2006 The Polycomb-associated protein Rybp is a ubiquitin binding protein.
17067581 2006 Modulation of HIV-1 Rev protein abundance and activity by polyubiquitination with unconventional Lys-33 branching.
17028573 2006 Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains.
17006543 2006 Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.
16997282 2006 NF-kappaB functions in the nervous system: from development to disease.
16996503 2006 Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells.
16936636 2006 MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology.
16892003 2006 Immunoreactivity of ubiquitin in human prostate gland.
16874301 2006 A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.
16874300 2006 The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation.
16845370 2006 The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
16810318 2006 Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
16763556 2006 Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin.
16543144 2006 Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.
16541075 2006 The finished DNA sequence of human chromosome 12.
16502470 2006 Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
16482222 2006 Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis.
16443603 2006 Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
16424905 2006 A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16256071 2005 CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.
15893736 2005 Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells.
15721744 2005 p75NTR--live or let die.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15466860 2004 Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.
15276183 2004 MD-2: the Toll 'gatekeeper' in endotoxin signalling.
15029244 2004 Mammalian Cdh1/Fzr mediates its own degradation.
14745543 2003 Lineage-specific homogenization of the polyubiquitin gene among human and great apes.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14559776 2003 The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity.
12944474 2003 Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis.
12923571 2003 The mechanical stability of ubiquitin is linkage dependent.
12883554 2003 A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter.
12857745 2003 Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone.
12813030 2003 Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane.
12791267 2003 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.
12787561 Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).
12750381 2003 Structure and ubiquitin binding of the ubiquitin-interacting motif.
12610113 2003 Retroviruses have differing requirements for proteasome function in the budding process.
12609980 2003 Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .
12507430 2002 Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12354939 2002 Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.
12230472 2002 Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.
12207904 2002 A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins.
11991975 2002 Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis.
11988742 2002 Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis.
11931757 2002 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
11916981 2002 Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates.
11872750 2002 Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1.
11827452 2002 Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis.
11689694 2001 Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways.
11584278 2001 Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.
11285280 2001 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.
11231585 2001 The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27.
11173499 2001 Structure of a new crystal form of tetraubiquitin.
11112487 2000 Ubiquitination of HIV-1 and MuLV Gag.
11087860 2000 A role for ubiquitin ligase recruitment in retrovirus release.
11087859 2000 Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.
11031247 2000 Secretory protein trafficking and organelle dynamics in living cells.
10882101 2000 TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
9644242 1998 Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product.
9525617 1998 Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus.
9504932 1998 Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus.
9488668 1998 Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a.
9110174 1997 Large-scale concatenation cDNA sequencing.
8917096 1996 Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells.
8702753 1996 p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins.
8619474 1996 A "double adaptor" method for improved shotgun library construction.
8570649 1996 Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting.
8166633 1994 Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin.
8107144 1994 Structure of tetraubiquitin shows how multiubiquitin chains can be formed.
3041007 1987 Structure of ubiquitin refined at 1.8 A resolution.
2988935 1985 The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.
2820408 1987 Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in human ovarian granulosa cells.
2564731 1989 Unequal crossover generates variation in ubiquitin coding unit number at the human UbC polyubiquitin locus.
1660345 1991 Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells.
1315303 1992 Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3.
1128706 1975 Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.
124018 1975 Hybrid troponin reconstituted from vertebrate and arthropod subunits.