Property Summary

NCBI Gene PubMed Count 157
Grant Count 13
Funding $1,301,364.14
PubMed Score 92.33
PubTator Score 97.64

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (3)

Disease log2 FC p
astrocytic glioma -1.200 0.033
lung cancer -4.100 0.038
ovarian cancer -2.400 0.007

Gene RIF (43)

PMID Text
25204743 Data suggest that both human ubiquitin and HFBII (hydrophobin-II from Trichoderma reesei) exhibit a critical surface hydration level (or effective hydrophobic interface at the surface) at which percolation transition of water network occurs.
24367661 UbB was significantly increased in prolonged Trichostatin A-selected HeLa cells and it played a key role in the maintenance of cervical cancer stem-like cells
24318982 A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex
24022007 downregulation of ubiquitin through Ubb-KD is a potential anti-cancer treatment by inhibiting ubiquitination at multiple sites related to oncogenic pathways and by weakening the ability of cancer cells to overcome increased stress.
22797007 A significant decrease in amyloid beta deposition and plaque formation suggests a role for the ubiquitin-proteasome system in the amyloid pathology of Alzheimer's disease.
22082077 age-dependent accumulation of Ubb(+1) , and how Ubb(+1) -mediated proteasome inhibition may contribute to Alzheimer's disease. [review]
21544573 Studies indicate that biomedical research on ubiquitin moves into translational research and drug discovery.
21480003 Studies indicate that DUBs recycle ubiquitin by processing polyubiquitin chains to generate free ubiquitin, and can be regulated by ubiquitination or phosphorylation.
21378163 analysis of orexin receptor 1 and 2 -arrestin-ubiquitin complexes
21059367 The results of this study demonstrated that the UBB mutation caused the subtle defect in spatial reference memory formation, caused by a decrease in forebrain proteasome activity.
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AA Sequence

MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV      1 - 70
LRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKE     71 - 140
STLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSD    141 - 210
YNIQKESTLHLVLRLRGGC                                                       211 - 229
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Text Mined References (163)

PMID Year Title
25527291 2015 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
25204743 2014 Protein-spanning water networks and implications for prediction of protein-protein interactions mediated through hydrophobic effects.
24784582 2014 Ubiquitin is phosphorylated by PINK1 to activate parkin.
24751536 2014 PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
24660806 2014 Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.
24367661 2013 Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters.
24022007 2013 Downregulation of ubiquitin level via knockdown of polyubiquitin gene Ubb as potential cancer therapeutic intervention.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
22797007 2012 Mutant ubiquitin decreases amyloid ? plaque formation in a transgenic mouse model of Alzheimer's disease.
22082077 2012 Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease.
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