Tdark SP9 Transcription factor Sp9

Protein Summary

Description

Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).

Uniprot Accession IDs

• P0CG40

Gene Name

• SP9

Ensembl ID

• ENST00000394967
• ENSP00000378418
• ENSG00000217236

Symbol

• ZNF990

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.78
cell type or tissue	0.73
transcription factor binding site profile	0.65
histone modification site profile	0.57
tissue sample	0.49

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Transcription Factor Sp9

Protein / Transcription Factor / Transcription Cofactor / Transcription Factor Sp9

Protein / Nucleic Acid Binding / Dna Binding Protein / Transcription Factor Sp9

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Transcription Factor Sp9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.74   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 20   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.74   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0