Property Summary

NCBI Gene PubMed Count 25
Grant Count 5
R01 Count 4
Funding $264,293.75
PubMed Score 66.92
PubTator Score 21.32

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (12)

Disease log2 FC p
osteosarcoma -2.330 0.000
adrenocortical carcinoma -1.235 0.024
non-small cell lung cancer -2.737 0.000
interstitial cystitis -1.800 0.001
pilocytic astrocytoma 1.300 0.006
breast carcinoma -1.500 0.000
spina bifida -1.662 0.042
Breast cancer -1.500 0.000
ductal carcinoma in situ -3.100 0.000
invasive ductal carcinoma -3.900 0.000
ulcerative colitis -1.300 0.000
ovarian cancer -1.900 0.000

Gene RIF (22)

PMID Text
24634214 Data indicate that phosphorylation of Gdown1 on Ser-270 reduces Its affinity for RNA polymerase II.
24596085 Modification of TFIIF provides one pathway through which efficient Gdown1 loading can occur early in elongation, allowing downstream pausing to be regulated.
23274668 A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1
23274668 A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1
23087374 A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1
23087374 A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1
23028129 A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1
22567366 A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1
22422068 A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1
22244332 Gdown1 competes with TFIIF for binding to the RPB1 and RPB5 subunits of Pol II, thereby inhibiting an essential function of TFIIF in preinitiation complex assembly.
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AA Sequence

MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSNGEPTRKLPQG      1 - 70
VVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSH     71 - 140
AQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQ    141 - 210
RQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEE    211 - 280
ANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLR    281 - 350
ERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE    351 - 420
VETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT                            421 - 466
//

Publication (28)

PMID Year Title
24634214 2014 Regulation of RNA polymerase II termination by phosphorylation of Gdown1.
24596085 2014 Functional interactions of the RNA polymerase II-interacting proteins Gdown1 and TFIIF.
22850672 2012 Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM.
22244332 2012 Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II.
22244331 2012 Functional association of Gdown1 with RNA polymerase II poised on human genes.
22231121 Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B.
21240187 2011 Cdc42-dependent formation of the ZO-1/MRCK? complex at the leading edge controls cell migration.
20412299 2010 Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A.
20093627 2010 Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.
18849881 2008 GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity.
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