UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Protein Summary
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
- ENST00000284440
- ENSP00000284440
- ENSG00000154277
- ENST00000503431
- ENSP00000422542
- NDGOA
- PARK5
- PGP95
- SPG79
- PGP9.5
- Uch-L1
- HEL-117
- PGP 9.5
- HEL-S-53
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.96 | ||
hub protein | 0.88 | ||
transcription factor perturbation | 0.88 | ||
gene perturbation | 0.85 | ||
virus perturbation | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2020.41 (req: < 5)
Gene RIFs: 255 (req: <= 3)
Antibodies: 1966 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2020.41 (req: >= 5)
Gene RIFs: 255 (req: > 3)
Antibodies: 1966 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0