Tchem ALPI Intestinal-type alkaline phosphatase

Protein Summary

Description

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• P09923
• B2R7Y4
• Q53S80
• Q9UBV5
• Q9UCL2
• IAP

Gene Name

• ALPI

Ensembl ID

• ENST00000295463
• ENSP00000295463
• ENSG00000163295

Symbol

• IAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.68
cell type or tissue	0.6
molecular function	0.6
cellular component	0.58
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Intestinal-type Alkaline Phosphatase

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Intestinal-type Alkaline Phosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.37   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 694   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.37   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 694   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0