Property Summary

NCBI Gene PubMed Count 246
Grant Count 331
R01 Count 192
Funding $38,158,295.39
PubMed Score 1353.02
PubTator Score 1830.01

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (63)

Disease Z-score Confidence
Asthma 349 5.306 2.7
Cancer 2,346 4.235 2.1
Atherosclerosis 275 4.045 2.0
Arthritis 248 3.957 2.0
Pleurisy 18 3.857 1.9
Alzheimer's disease 644 3.324 1.7
Rhinitis 46 3.294 1.6
Allergic hypersensitivity disease 123 3.053 1.5
ASTHMA, DIMINISHED RESPONSE TO ANTILEUKO... 1 
ATHEROSCLEROSIS, SUSCEPTIBILITY TO 3
Adenoma 165
Allergic asthma 6
Asthma management 20
Breast cancer 3,094
Chronic ulcerative proctitis 7
Chronic ulcerative rectosigmoiditis 4
Colitis 46
Colonic Neoplasms 126
Colonic Polyps 3
Drug Eruptions 18
Dysmenorrhea 19
Endometriosis 535
Endotoxemia 8
Hyperalgesia 71
Infarction, Middle Cerebral Artery 25
Juvenile rheumatoid arthritis 104
Menorrhagia 8
Multiple Organ Failure 6
Myeloid Leukemia, Chronic 22
Neoplasm Invasiveness 127
Neoplasm Metastasis 138
Non-allergic asthma 5
Osteoarthritis 96
Pain 70
Pulmonary hypertension 52
Reperfusion Injury 84
Rheumatoid Arthritis 1,160
Stomach Neoplasms 282
Ulcerative colitis in remission 4
Urticaria 53
adrenocortical carcinoma 1,427
astrocytoma 1,493
chronic kidney disease 90
cystic fibrosis 1,665
dermatomyositis 933
glioblastoma 5,572
group 4 medulloblastoma 1,875
interstitial cystitis 2,299
invasive ductal carcinoma 2,950
lung adenocarcinoma 2,713
lung cancer 4,466
lung carcinoma 2,844
medulloblastoma, large-cell 6,234
mucosa-associated lymphoid tissue lympho... 480 
non-small cell lung cancer 2,798
osteosarcoma 7,933
ovarian cancer 8,484
pancreatic ductal adenocarcinoma liver m... 1,795 
periodontitis 269
pilocytic astrocytoma 3,086
primary Sjogren syndrome 789
psoriasis 6,685
ulcerative colitis 2,087

Expression

  Differential Expression (25)

Disease log2 FC p
psoriasis 1.100 0.009
glioblastoma 3.000 0.000
osteosarcoma -3.644 0.001
group 4 medulloblastoma -2.000 0.000
astrocytoma 2.500 0.038
periodontitis 1.100 0.000
medulloblastoma, large-cell -2.900 0.000
adrenocortical carcinoma -2.125 0.002
chronic kidney disease 2.500 0.004
pancreatic ductal adenocarcinoma liver m... 2.241 0.030
non-small cell lung cancer -3.025 0.000
lung cancer -4.400 0.000
interstitial cystitis -2.100 0.000
cystic fibrosis -2.700 0.000
pilocytic astrocytoma 1.500 0.000
primary Sjogren syndrome 2.000 0.000
lung adenocarcinoma -2.001 0.000
invasive ductal carcinoma 2.442 0.000
Endometriosis -1.173 0.037
lung carcinoma -2.100 0.000
Breast cancer -2.100 0.000
mucosa-associated lymphoid tissue lympho... 2.068 0.011
ulcerative colitis 3.400 0.000
ovarian cancer 3.500 0.000
dermatomyositis 1.400 0.002

Synonym

Accession P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 5-LO
Symbols 5-LO
5LPG
LOG5
5-LOX

Gene

PANTHER Protein Class (2)

PDB

2ABV   3O8Y   3V92   3V98   3V99  

Gene RIF (231)

PMID Text
26852002 the Alox-5 gene might play a role in the differentiation of multiple drug resistant and non-resistant erythroleukemic cell lines
26707712 our data suggest that the inhibition of both COX-2/5-LOX may be an effective therapeutic approach for colon cancer management, particularly for those patients with high expression of COX-2/5-LOX
26505400 we identified differences in the frequency distribution in the Tibetan population located in the ALOX5 , VKORC1 and PTGS2 genes
26427761 The study explores the substrate access portal of 5-Lipoxygenase.
26378572 Increased PUFA Content and 5-lipoxygenase pathway expression are associated with subcutaneous adipose tissue inflammation in obese women with type 2 diabetes.
26334317 These results suggest that COX-2 and 5-LO play roles in tumorigenesis and the progression of primary glioblastoma and that the co-expression pattern of COX-2/5-LO may be used as an independent prognostic factor in this disease.
26329759 AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3.
26327594 THE 5-LOX interface involving the four cysteines 159, 300, 416 and 418 is important for the translocation to the nuclear membrane and the colocalization with FLAP.
26210919 The study shows that 5-lipoxygenase (5-LO) in B cells is phosphorylated on Ser523 and demonstrates for the first time a chemical difference between 5-LO in myeloid cells and B cells.
26173130 investigated potential mechanisms by which 5-LO13 interferes with 5-LO product biosynthesis in transfected HEK293 cells
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AA Sequence

MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRI      1 - 70
EKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQ     71 - 140
KQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEK    141 - 210
IFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQG    211 - 280
NIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLL    281 - 350
AKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECG    351 - 420
LFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVV    421 - 490
DIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYD    491 - 560
WCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKP    561 - 630
VKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI                              631 - 674
//

Text Mined References (250)

PMID Year Title
26852002 2016 Cell differentiation and the multiple drug resistance phenotype in human erythroleukemic cells.
26707712 2016 Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro.
26505400 2015 Genetic polymorphisms in very important pharmacogenomic (VIP) variants in the Tibetan population.
26427761 2015 Identification of the Substrate Access Portal of 5-Lipoxygenase.
26378572 2015 Increased PUFA Content and 5-Lipoxygenase Pathway Expression Are Associated with Subcutaneous Adipose Tissue Inflammation in Obese Women with Type 2 Diabetes.
26334317 2015 Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis.
26329759 2015 AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3.
26327594 2015 Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP.
26210919 2015 Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.
26173130 2015 The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase ?13 Isoform Differs from That of Its Full Length Counterpart.
More...