Property Summary

NCBI Gene PubMed Count 21
PubMed Score 16.00
PubTator Score 69.99

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count
Influenza 142
Spontaneous abortion 108
Disease Target Count P-value
breast carcinoma 1614 1.39121469158382E-16
juvenile dermatomyositis 1189 1.07959980669019E-15
psoriasis 6685 3.98367250369054E-10
malignant mesothelioma 3163 7.15807822044486E-9
Duchenne muscular dystrophy 602 1.02935360817083E-7
lung cancer 4473 2.32942215972783E-6
medulloblastoma, large-cell 6234 5.31383463645156E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 8.53999262603043E-5
pancreatic cancer 2300 8.73562916847886E-5
systemic lupus erythematosus 172 1.31726720847173E-4
osteosarcoma 7933 1.68009395616814E-4
cutaneous lupus erythematosus 1056 3.50472747907138E-4
Multiple myeloma 1328 4.32930638630025E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 5.15213748797499E-4
non-inflammatory breast cancer 208 5.35834570785378E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 5.45825187138932E-4
Multiple Sclerosis 498 6.47132479954233E-4
Atopic dermatitis 944 0.0010335708931591
cystic fibrosis 1670 0.00171504428137677
active ulcerative colitis 477 0.00461602809333549
tuberculosis 1563 0.00588152324336224
ovarian cancer 8492 0.0059421360414569
active Crohn's disease 918 0.0059812559935352
group 4 medulloblastoma 1875 0.00748152521961927
invasive ductal carcinoma 2950 0.00858849786229163
posterior fossa group B ependymoma 1530 0.0121790978830514
primary Sjogren syndrome 789 0.0170423188004808
pilocytic astrocytoma 3086 0.0273514892590818



Accession P09912 Q13141 Q13142 Q5VVR2 Q5VVR3 Q6IE95 Q969M8
Symbols 6-16


  Ortholog (6)

Species Source
Chimp OMA EggNOG Inparanoid
Macaque OMA EggNOG
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA Inparanoid

Gene RIF (11)

26116899 HIV-1 Vpr upregulates the gene expression of IFI6 in human monocyte-derived dendritic cells
26105982 In conclusion, over-expression of IFI6 promotes hepatitis C virus RNA replication and rescues the interferon alpha-mediated anti-hepatitis C virus activity.
25757571 IFI6 inhibits HCV entry by impairing EGFR mediated CD81/CLDN1 interactions. This may be relevant to other virus entry processes employing EGFR.
24162774 HIV-1 Vpr upregulates the gene expression of IFI6 in human monocyte-derived dendritic cells
21996729 Here we elucidate G1P3, a survival protein induced by interferons (IFNs), as a target of estrogen signaling and a contributor to poor outcomes in estrogen receptor-positive (ER(+)) breast cancer.
20628624 Meta-analysis of gene-disease association. (HuGE Navigator)
20377629 PRINS regulates G1P3, a gene with anti-apoptotic effects in keratinocytes. siRNA-mediated inhibition of PRINS gene resulted in altered cell morphology and gene expression alterations.
20237496 Observational study of gene-disease association. (HuGE Navigator)
18838000 Respiratory syncytial virus upregulated the mRNA expression of chemokines CC and CXC and interfered with type alpha/beta interferon-inducible gene expression by upregulation of MG11 and downregulation of G1P3.
17823654 IFN-alpha2b induced the expression of G1P3 and antagonized the TRAIL induced apoptosis in myeloma suggesting that either the deregulated or the induced expression of G1P3 could lead to apoptosis resistance in tumor cells.

AA Sequence


Text Mined References (23)

PMID Year Title
26105982 2016 Interferon-inducible Protein 6-16 (IFI-6-16, ISG16) promotes Hepatitis C virus replication in vitro.
25757571 2015 Interferon-? inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection.
25539662 2014 No transmission of hepatitis E virus in pigs fed diets containing commercial spray-dried porcine plasma: a retrospective study of samples from several swine trials.
21996729 2012 G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer.
20628624 2010 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
20377629 2010 The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
18838000 2008 Inhibition of G1P3 expression found in the differential display study on respiratory syncytial virus infection.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17823654 2007 G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.