Tclin TACSTD2 Tumor-associated calcium signal transducer 2

Protein Summary

Description

May function as a growth factor receptor. This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• P09758
• Q15658
• Q6FG48
• Q7Z7Q4
• Q96QD2

Gene Name

• TACSTD2

Ensembl ID

• ENST00000371225
• ENSP00000360269
• ENSG00000184292

Symbol

• GA733-1
• M1S1
• TROP2
• EGP1
• GP50
• M1S1
• EGP-1
• TROP2
• GA7331
• GA733-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
gene perturbation	0.91
virus perturbation	0.85
transcription factor perturbation	0.74
cellular component	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 566.49   (req: < 5)

Gene RIFs: 127   (req: <= 3)

Antibodies: 546   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 566.49   (req: >= 5)

Gene RIFs: 127   (req: > 3)

Antibodies: 546   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1