Property Summary

NCBI Gene PubMed Count 27
PubMed Score 63.02
PubTator Score 38.45

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
ovarian cancer 8492 1.28199970010775E-14
juvenile dermatomyositis 1189 1.48021232069482E-9
non-small cell lung cancer 2798 1.99868728289364E-7
psoriasis 6685 1.57195583961946E-6
intraductal papillary-mucinous neoplasm (IPMN) 3289 3.03701947503208E-6
cystic fibrosis 1670 3.08825637557618E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 5.80787306025485E-6
malignant mesothelioma 3163 1.70295899857921E-5
pancreatic cancer 2300 6.51976383854537E-5
nasopharyngeal carcinoma 1056 6.99087058574082E-5
glioblastoma 5572 1.39565136349582E-4
medulloblastoma, large-cell 6234 5.2730937346468E-4
osteosarcoma 7933 5.60180419451754E-4
pediatric high grade glioma 2712 6.4826180007375E-4
dermatomyositis 967 0.00175479824693669
colon cancer 1475 0.00206139796019534
cutaneous lupus erythematosus 1056 0.00850786247939118
group 3 medulloblastoma 2254 0.0185239240245259
atypical teratoid / rhabdoid tumor 4369 0.027145424464818
primitive neuroectodermal tumor 3031 0.0373644911169581
adrenocortical adenoma 134 0.0388285545052124
pilocytic astrocytoma 3086 0.0448550959650274
Disease Target Count Z-score Confidence
Osteoporosis 259 0.0 2.0
Disease Target Count Z-score Confidence
Cancer 2346 3.201 1.6



Accession P09630 B2RBV2 Q6DK09
Symbols CP25


  Ortholog (10)

Gene RIF (11)

26310814 HOXC6 has a role in all prostate cancer stages, particularly in prostate cancer cell proliferation.
26046583 Data demonstrate significant downregulation of HOXC6 in serous ovarian cancer and low protein level is associated with high-grade tumors.
25725483 Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA, in vitro and in vivo.
24525058 HOXC6 can be used as a prognostic marker in esophageal squamous cell carcinoma
23581417 Hoxc6 might contribute to the progression of gastric carcinogenesis and may be a significant predictor of poor survival in patients with gastric cancer after curative operations.
22907429 HOXC6 expression is an important mechanism of chemotherapeutic drug resistance via its regulation of MDR-1
22896703 HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression.
21683083 These studies demonstrated that HOXC6 is an estrogen-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha and ERbeta, transcriptionally regulate HOXC6 in an estrogen-dependent manner.
19236766 Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 in lymphocytic progenitor cells.
17488478 HOXC6 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells.

AA Sequence

GGATADSLGGKEEKREETEEEKQKE                                                 211 - 235

Text Mined References (28)

PMID Year Title
26310814 2015 The role of HOXC6 in prostate cancer development.
26046583 2015 Downregulation of HOXC6 in Serous Ovarian Cancer.
25725483 2015 Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer.
24525058 2014 The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma.
23581417 2013 Upregulated Hoxc6 expression is associated with poor survival in gastric cancer patients.
22907429 2013 Transcriptional regulation of MDR-1 by HOXC6 in multidrug-resistant cells.
22896703 2012 HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression.
22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
21683083 2011 HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.
19236766 2009 [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells].