Property Summary

NCBI Gene PubMed Count 252
PubMed Score 1078.87
PubTator Score 714.67

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count P-value
urothelial carcinoma 318 1.38788466046107E-12
juvenile dermatomyositis 1189 5.88718439079714E-9
posterior fossa group A ependymoma 1511 5.97938905090795E-9
pilocytic astrocytoma 3086 1.26416378909984E-8
Duchenne muscular dystrophy 602 4.48435896071295E-8
pediatric high grade glioma 2712 2.30935605352173E-6
ovarian cancer 8492 3.91254958593905E-6
nasopharyngeal carcinoma 1056 4.83087209268655E-6
atypical teratoid / rhabdoid tumor 4369 9.44524449514043E-6
pancreatic cancer 2300 1.78073894883871E-5
ulcerative colitis 2087 2.2883778931657E-5
limb girdle muscular dystrophy 2A 156 8.12096297445202E-5
primary pancreatic ductal adenocarcinoma 1271 8.6353550832215E-5
cystic fibrosis 1670 1.43727879908471E-4
pancreatic carcinoma 567 1.93573477537025E-4
group 4 medulloblastoma 1875 5.44648198450408E-4
medulloblastoma, large-cell 6234 5.70243207035126E-4
Down syndrome 548 8.29228901552851E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 9.56682358247591E-4
astrocytoma 1493 0.00170190973625988
invasive ductal carcinoma 2950 0.00205055445148895
oligodendroglioma 2849 0.00235551147947425
hepatocellular carcinoma 550 0.00296931644375473
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00298628469903197
Atopic dermatitis 944 0.00350478414009619
primitive neuroectodermal tumor 3031 0.00564641486083369
acute myeloid leukemia 785 0.00567618490906407
gastric carcinoma 832 0.00657793684719461
inflammatory breast cancer 404 0.00697847138517802
glioblastoma 5572 0.0110049038977089
Becker muscular dystrophy 187 0.011882510724154
pterygium 74 0.0218580462022956
esophageal adenocarcinoma 737 0.0234033180629823
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0283695433234491
chronic kidney disease 90 0.0356099858680912
subependymal giant cell astrocytoma 2287 0.0379855514239005
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0450181827007193
primary Sjogren syndrome 789 0.0492745015603429
Disease Target Count
Osteogenesis imperfecta 17 1



Accession P09486 D3DQH9 Q6IBK4
Symbols ON



2V53   1BMO   1NUB   1SRA  

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA Inparanoid

Gene RIF (207)

27069189 We identified five new biomarkers: GDF15, osteonectin, TRAP5, TWEAK, and YKL40 as being promising markers for monitoring bone metastases.
26731428 SPARC might be an unfavorable indicator in patients with pancreatic cancer, especially in the stroma.[Review]
26656750 tracheal aspirate SPARC levels predicted development of bronchopulmonary dysplasia or death.
26523779 high SPARC-expression was a significant predictor of poor OS in HPV-negative OPSCC patients using Kaplan-Meier analysis and the log-rank test
26335014 Studies indicate that SPARC (secreted protein acidic and rich in cysteine) gene is involved in the development and progression of pancreatic ductal adenocarcinoma (PDAC).
26329007 CD90 is upregulated in gastric cancer and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC protein.
26169969 SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.
26165695 MLKL upregulation in SPARC overexpressed cells treated with Ara-C, indicates necrosis as a possible cell death process for the SKM-1 cells under these stringent conditions.
26044224 Reduced expression of SPARC in colorectal cancer tissue is associated with poor prognosis and aggressive clinicopathological features.
26027498 Recessive osteogenesis imperfecta caused by missense mutations in SPARC.

AA Sequence

IALDEWAGCFGIKQKDIDKDLVI                                                   281 - 303

Text Mined References (254)

PMID Year Title
27069189 2016 Testing of a Novel Cancer Metastatic Multiplex Panel for the Detection of Bone-metastatic Disease - a Pilot Study.
26731428 2016 Prognostic Value of SPARC in Patients with Pancreatic Cancer: A Systematic Review and Meta-Analysis.
26656750 2015 Tracheal Aspirate Levels of the Matricellular Protein SPARC Predict Development of Bronchopulmonary Dysplasia.
26523779 2016 Expression of secreted protein acidic and rich in cysteine is an independent prognostic indicator of a poor clinical outcome in oropharyngeal carcinoma patients.
26335014 2015 SPARC: A Potential Prognostic and Therapeutic Target in Pancreatic Cancer.
26329007 2015 CD90 is upregulated in gastric cancer tissues and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC protein.
26169969 2015 SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial.
26165695 2015 SPARC ectopic overexpression inhibits growth and promotes programmed cell death in acute myeloid leukemia transformed from myelodysplastic syndrome cells, alone and in combination with Ara-C treatment.
26044224 2015 Secreted protein acidic and rich in cysteine expression in human colorectal cancer predicts postoperative prognosis.
26027498 2015 Recessive osteogenesis imperfecta caused by missense mutations in SPARC.