Property Summary

NCBI Gene PubMed Count 51
Grant Count 144
R01 Count 67
Funding $14,387,619.02
PubMed Score 359.48
PubTator Score 151.98

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (20)

Synonym

Accession P09326 Q5U055 Q8MGR0
Symbols BCM1
BLAST
hCD48
mCD48
BLAST1
SLAMF2
MEM-102

Gene

PDB

2EDO  

 GO Function (1)

Gene RIF (28)

PMID Text
26926492 CD48 expression was increased in patients with a short disease duration compared to both controls and patients with longer disease duration. In patients with short disease duration, increased CD48 expression was associated with alveolar inflammation.
25275127 Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD48 (SLAMF2)
25275127 Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD48 (SLAMF2)
25255823 These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD.
24670806 we propose that SLAMF2 engagement regulates adaptive immune responses
24505299 Blockade of 2B4/CD48 interaction resulted in improvement in function via perforin expression and degranulation as measured by CD107a surface mobilization on HTLV-1 specific CD8+ T cells.
23225218 Monocyte-induced natural killer cell dysfunction was markedly attenuated by blocking CD48 receptor 2B4 on NK cells, but not by blockade of NKG2D and NKp30.
22495247 replication study of association of 2 SNPs in HERV-K18 and 19 tagSNPs in CD48 with schizophrenia (SZ)and type 2 diabetes (T2D) in patients with SZ in 2 Danish samples; no association was found with SZ or with T2D among individuals with SZ for any of the SNPs
20833258 Stimulation of CD48 induces rearrangement of signaling factors in lipid rafts, Lck-kinase activity, and tyrosine phosphorylation.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
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AA Sequence

MCSRGWDSCLALELLLLPLSLLVTSIQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWD      1 - 70
SRKSKYFESKFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEK     71 - 140
IEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVC    141 - 210
LSPPCTLARSFGVEWIASWLVVTVPTILGLLLT                                         211 - 243
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Text Mined References (52)

PMID Year Title
26926492 2016 CD81 and CD48 show different expression on blood eosinophils in systemic sclerosis: new markers for disease and pulmonary inflammation?
25255823 2014 The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation.
24670806 2014 Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival.
24505299 2014 HTLV-1 specific CD8+ T cell function augmented by blockade of 2B4/CD48 interaction in HTLV-1 infection.
23225218 2013 Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
22495247 2012 No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia.
20833258 2011 CD48: A co-stimulatory receptor of immunity.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
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