Tchem GSTP1 Glutathione S-transferase P

Protein Summary

Description

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09211
• O00460
• Q15690
• Q5TZY3

Gene Name

• GSTP1

Ensembl ID

• ENST00000398606
• ENSP00000381607
• ENSG00000084207
• ENST00000642444
• ENSP00000493538

Symbol

• FAEES3
• GST3
• PI
• DFN7
• GST3
• GSTP
• FAEES3
• HEL-S-22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
transcription factor perturbation	0.99
biological process	0.97
disease perturbation	0.97
cell type or tissue	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2508.52   (req: < 5)

Gene RIFs: 995   (req: <= 3)

Antibodies: 735   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2508.52   (req: >= 5)

Gene RIFs: 995   (req: > 3)

Antibodies: 735   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2