POU2F2
POU domain, class 2, transcription factor 2
Protein Summary
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000389341
- ENSP00000373992
- ENSG00000028277
- ENST00000526816
- ENSP00000431603
- ENST00000529067
- ENSP00000437224
- ENST00000529952
- ENSP00000436988
- OCT2
- OTF2
- OCT2
- OTF2
- Oct-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
biological process | 0.72 | ||
transcription factor | 0.62 | ||
histone modification site profile | 0.61 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 45.57 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 525 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 45.57 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 525 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0