Tclin HTR1A 5-hydroxytryptamine receptor 1A

Protein Summary

Description

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• P08908
• Q6LAE7
• 5-HT-1A

Gene Name

• HTR1A

Ensembl ID

• ENST00000323865
• ENSP00000316244
• ENSG00000178394

Symbol

• ADRB2RL1
• ADRBRL1
• G-21
• 5HT1a
• PFMCD
• 5-HT1A
• 5-HT-1A
• ADRBRL1
• ADRB2RL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
ligand (chemical)	1
disease	0.95
chemical	0.92
protein complex	0.81

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / 5-hydroxytryptamine Receptor 1a

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / 5-hydroxytryptamine Receptor / 5-ht1 Receptor / 5-hydroxytryptamine Receptor 1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7223.31   (req: < 5)

Gene RIFs: 304   (req: <= 3)

Antibodies: 296   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7223.31   (req: >= 5)

Gene RIFs: 304   (req: > 3)

Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3125

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 46