Property Summary

NCBI Gene PubMed Count 162
PubMed Score 6426.86
PubTator Score 4068.02

Knowledge Summary


No data available


  Disease Sources (6)

Disease Target Count P-value
lung carcinoma 2844 2.24070881503155E-16
posterior fossa group A ependymoma 1511 2.63592039658821E-13
juvenile dermatomyositis 1189 1.71594187389349E-11
pilocytic astrocytoma 3086 1.78495908166618E-10
ovarian cancer 8492 8.44946385445579E-10
pediatric high grade glioma 2712 1.64789395104051E-8
Duchenne muscular dystrophy 602 1.9232993256279E-8
ulcerative colitis 2087 1.69779318248597E-7
osteosarcoma 7933 1.92399247801262E-6
glioblastoma 5572 3.19484149502866E-4
acute quadriplegic myopathy 1157 4.39192247575254E-4
lung cancer 4473 4.71630889204426E-4
Down syndrome 548 6.78053879792689E-4
Multiple myeloma 1328 8.37176886852933E-4
sonic hedgehog group medulloblastoma 1482 8.76748807155514E-4
atypical teratoid / rhabdoid tumor 4369 0.00118650010797345
tuberculosis and treatment for 6 months 686 0.0019886920834327
astrocytoma 1493 0.00273903391586518
pancreatic cancer 2300 0.00301525835268935
active Crohn's disease 918 0.00463847215628787
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00908973919672614
subependymal giant cell astrocytoma 2287 0.0165423459957572
breast carcinoma 1614 0.0290595968718901
Disease Target Count Z-score Confidence
Chronic obstructive pulmonary disease 147 0.0 1.0
Disease Target Count
Pregnancy loss, recurrent, 3 1



Accession P08758 D3DNW7 Q6FHB3 Q6FI16 Q8WV69 Q9UDH9
Symbols PP4



1ANW   1ANX   1AVH   1AVR   1HAK   1HVD   1HVE   1HVF   1HVG   1SAV   2XO2   2XO3  

  Ortholog (13)

Gene RIF (124)

26371709 The M2 haplotype is a risk factor for early spontaneous abortions, before the 12th week of gestation, and confers about the same relative risk to carriers of both sexes.
26160872 Chronically increased alveolar annexin V levels, as reflected in increased idiopathic pulmonary fibrosis (IPF) BALF levels, may contribute to the progression of IPF by inducing the release of pro-fibrotic mediators.
26135579 annexin A5 promoter haplotype M2 may not have a role in recurrent pregnancy loss in Estonia or Denmark
25899647 Annexin V is fused to an enzyme, creating a fusion protein that converts nontoxic drug precursors, prodrugs, into anticancer compounds while bound to the tumor, therefore mitigating the risk of side effects.
25799159 Anx5 could protect cardiomyocytes adherens junctions and improve myocardial contractile function via regulation of p120 and anti-inflammation in LPS-induced endotoxemia.
25796304 lower exhaled breath condensate annexin A5 levels in children with exercise-induced asthma compared to non-exercised-induced one
25682309 The associated male partner risk confirms the proposed role of M2/ANXA5 as a genetic trait impeding embryonic anticoagulation.
25661914 The prognostic value of AnV and T cell apoptosis was evaluated in children with nephrotic syndrome in this review.
25595530 AnxA5 promotes membrane resealing of injured human trophoblasts.
25525746 ANXA5 haplotypes/plasma ANXA5 levels were not associated with carotid IMT progression or cardiovascular disease risk in familial hypercholesterolemia patients.

AA Sequence

LFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD                                  281 - 320

Text Mined References (173)

PMID Year Title
26371709 2015 Investigation of the Annexin A5 M2 haplotype in 500 white European couples who have experienced recurrent spontaneous abortion.
26160872 2015 Increased alveolar soluble annexin V promotes lung inflammation and fibrosis.
26135579 2015 Annexin A5 Promoter Haplotype M2 Is Not a Risk Factor for Recurrent Pregnancy Loss in Northern Europe.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25899647 2015 Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer.
25799159 2015 Recombinant Human Annexin A5 Can Repair the Disrupted Cardiomyocyte Adherens Junctions in Endotoxemia.
25796304 Exhaled breath condensate annexin A5 levels in exercise-induced bronchoconstriction in asthma: A preliminary study.
25772364 2015 SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.
25682309 2015 M2/ANXA5 haplotype as a predisposition factor in Malay women and couples experiencing recurrent spontaneous abortion: a pilot study.
25661914 2015 [Importance of annexin V in kidney diseases].