Tclin MME Neprilysin

Protein Summary

Description

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P08473
• A8K6U6
• D3DNJ9
• Q3MIX4

Gene Name

• MME

Ensembl ID

• ENST00000360490
• ENSP00000353679
• ENSG00000196549
• ENST00000460393
• ENSP00000418525
• ENST00000462745
• ENSP00000419653
• ENST00000492661
• ENSP00000420389
• ENST00000493237
• ENSP00000417079
• ENST00000615825
• ENSP00000478173

Symbol

• EPN
• NEP
• SFE
• CD10
• CALLA
• CMT2T
• SCA43

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.95
cellular component	0.8
disease	0.78
protein domain	0.73
hub protein	0.71

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Neprilysin

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Neprilysin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6023.3   (req: < 5)

Gene RIFs: 290   (req: <= 3)

Antibodies: 2082   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6023.3   (req: >= 5)

Gene RIFs: 290   (req: > 3)

Antibodies: 2082   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 394

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2